tert-butyl (5S,6R)-5-tert-butyldimethylsilanyloxy-7-(4-methoxybenzyloxy)-6-methylhept-2(E)-enoate

Base Information

Chemical Name:tert-butyl (5S,6R)-5-tert-butyldimethylsilanyloxy-7-(4-methoxybenzyloxy)-6-methylhept-2(E)-enoate
CAS No.:219606-75-4
Molecular Formula:C₂₆H₄₄O₅Si
Molecular Weight:464.718
Hs Code.:

Synonyms:tert-butyl (5S,6R)-5-tert-butyldimethylsilanyloxy-7-(4-methoxybenzyloxy)-6-methylhept-2(E)-enoate

Suppliers and Price of tert-butyl (5S,6R)-5-tert-butyldimethylsilanyloxy-7-(4-methoxybenzyloxy)-6-methylhept-2(E)-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (5S,6R)-5-tert-butyldimethylsilanyloxy-7-(4-methoxybenzyloxy)-6-methylhept-2(E)-enoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl (5S,6R)-5-tert-butyldimethylsilanyloxy-7-(4-methoxybenzyloxy)-6-methylhept-2(E)-enoate

There total 5 articles about tert-butyl (5S,6R)-5-tert-butyldimethylsilanyloxy-7-(4-methoxybenzyloxy)-6-methylhept-2(E)-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 86302-43-4,35000-38-5
(tert-Butoxycarbonylmethylene)triphenylphosphorane

: 219606-74-3
(3S,4R)-3-tert-butyldimethylsilanyloxy-5-(4-methoxybenzyloxy)-4-methylpentanal

: 219606-75-4
tert-butyl (5S,6R)-5-tert-butyldimethylsilanyloxy-7-(4-methoxybenzyloxy)-6-methylhept-2(E)-enoate

Guidance literature:: In dichloromethane; Ambient temperature;
DOI:10.1016/S0040-4039(98)02014-0

Reference yield:

: 160238-46-0
(2R)-3-(4-methoxybenzyloxy)-2-methyl-1-propanal

: 219606-75-4
tert-butyl (5S,6R)-5-tert-butyldimethylsilanyloxy-7-(4-methoxybenzyloxy)-6-methylhept-2(E)-enoate

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / tin tetrachloride / CH₂Cl₂ / 1 h / -100 °C

2: 95 percent / imidazole / dimethylformamide / 18 h / 20 °C

3: 77 percent / OsO₄; NaIO₄ / tetrahydrofuran; H₂O; 2-methyl-propan-2-ol / 20 h / 20 °C

4: 95 percent / CH₂Cl₂ / 20 h / 20 °C

With 1H-imidazole; sodium periodate; osmium(VIII) oxide; tin(IV) chloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1: allylation / 2: Etherification / 3: Oxidation / 4: Substitution;
DOI:10.1021/jo9907585

Reference yield:

: 203926-55-0
(2R,3S)-1-[(4-methoxyphenyl)methoxy]-2-methyl-5-hexen-3-ol

: 219606-75-4
tert-butyl (5S,6R)-5-tert-butyldimethylsilanyloxy-7-(4-methoxybenzyloxy)-6-methylhept-2(E)-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / imidazole / dimethylformamide / 18 h / 20 °C

2: 77 percent / OsO₄; NaIO₄ / tetrahydrofuran; H₂O; 2-methyl-propan-2-ol / 20 h / 20 °C

3: 95 percent / CH₂Cl₂ / 20 h / 20 °C

With 1H-imidazole; sodium periodate; osmium(VIII) oxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1: Etherification / 2: Oxidation / 3: Substitution;
DOI:10.1021/jo9907585