3-{(1E)-3-[(2R)-2-(3,5-difluorophenyl)-2,5,5-trimethyl-6-oxopiperazin-1-yl]prop-1-en-1-yl}-5,7-dihydrospiro[cyclopenta[c]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Base Information

Chemical Name:3-{(1E)-3-[(2R)-2-(3,5-difluorophenyl)-2,5,5-trimethyl-6-oxopiperazin-1-yl]prop-1-en-1-yl}-5,7-dihydrospiro[cyclopenta[c]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one
CAS No.:1189569-39-8
Molecular Formula:C₃₀H₂₉F₂N₅O₂
Molecular Weight:529.589
Hs Code.:

3-{(1E)-3-[(2R)-2-(3,5-difluorophenyl)-2,5,5-trimethyl-6-oxopiperazin-1-yl]prop-1-en-1-yl}-5,7-dihydrospiro[cyclopenta[c]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Synonyms:3-{(1E)-3-[(2R)-2-(3,5-difluorophenyl)-2,5,5-trimethyl-6-oxopiperazin-1-yl]prop-1-en-1-yl}-5,7-dihydrospiro[cyclopenta[c]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Suppliers and Price of 3-{(1E)-3-[(2R)-2-(3,5-difluorophenyl)-2,5,5-trimethyl-6-oxopiperazin-1-yl]prop-1-en-1-yl}-5,7-dihydrospiro[cyclopenta[c]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-{(1E)-3-[(2R)-2-(3,5-difluorophenyl)-2,5,5-trimethyl-6-oxopiperazin-1-yl]prop-1-en-1-yl}-5,7-dihydrospiro[cyclopenta[c]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of 3-{(1E)-3-[(2R)-2-(3,5-difluorophenyl)-2,5,5-trimethyl-6-oxopiperazin-1-yl]prop-1-en-1-yl}-5,7-dihydrospiro[cyclopenta[c]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

There total 13 articles about 3-{(1E)-3-[(2R)-2-(3,5-difluorophenyl)-2,5,5-trimethyl-6-oxopiperazin-1-yl]prop-1-en-1-yl}-5,7-dihydrospiro[cyclopenta[c]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₆H₄₃F₂N₅O₃Si

: 1189569-39-8
3-{(1E)-3-[(2R)-2-(3,5-difluorophenyl)-2,5,5-trimethyl-6-oxopiperazin-1-yl]prop-1-en-1-yl}-5,7-dihydrospiro[cyclopenta[c]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Guidance literature:: With ethylenediamine; sodium hydroxide; In methanol; at 20 ℃; for 12h;

Reference yield:

: 271-63-6
7-Azaindole

: 1189569-39-8
3-{(1E)-3-[(2R)-2-(3,5-difluorophenyl)-2,5,5-trimethyl-6-oxopiperazin-1-yl]prop-1-en-1-yl}-5,7-dihydrospiro[cyclopenta[c]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.42 h / 0 °C

1.2: 1.25 h / 10 °C

2.1: pyridinium hydrobromide perbromide / 1,4-dioxane / 1 h / 20 °C

3.1: water

4.1: ammonium chloride; zinc / tetrahydrofuran; water / 3 h

5.1: caesium carbonate / N,N-dimethyl-formamide / 21 h

6.1: N-Methyldicyclohexylamine / bis(tri-tert-butylphosphine)palladium⁽⁰⁾ / dimethyl amine / 0.33 h / 150 °C / Microwave irradiation

7.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

8.1: ethylenediamine; sodium hydroxide / methanol / 12 h / 20 °C

With N-Methyldicyclohexylamine; water; pyridinium hydrobromide perbromide; sodium hydride; ammonium chloride; caesium carbonate; ethylenediamine; trifluoroacetic acid; sodium hydroxide; zinc; bis(tri-tert-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl amine; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 879132-46-4
1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine

: 1189569-39-8
3-{(1E)-3-[(2R)-2-(3,5-difluorophenyl)-2,5,5-trimethyl-6-oxopiperazin-1-yl]prop-1-en-1-yl}-5,7-dihydrospiro[cyclopenta[c]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: pyridinium hydrobromide perbromide / 1,4-dioxane / 1 h / 20 °C

2: water

3: ammonium chloride; zinc / tetrahydrofuran; water / 3 h

4: caesium carbonate / N,N-dimethyl-formamide / 21 h

5: N-Methyldicyclohexylamine / bis(tri-tert-butylphosphine)palladium⁽⁰⁾ / dimethyl amine / 0.33 h / 150 °C / Microwave irradiation

6: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

7: ethylenediamine; sodium hydroxide / methanol / 12 h / 20 °C

With N-Methyldicyclohexylamine; water; pyridinium hydrobromide perbromide; ammonium chloride; caesium carbonate; ethylenediamine; trifluoroacetic acid; sodium hydroxide; zinc; bis(tri-tert-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl amine; N,N-dimethyl-formamide;