N-((4S,6S)-4-(5-amino-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

Base Information

Chemical Name:N-((4S,6S)-4-(5-amino-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide
CAS No.:1624603-17-3
Molecular Formula:C₁₉H₁₆F₅N₃O₂
Molecular Weight:413.347
Hs Code.:

Synonyms:N-((4S,6S)-4-(5-amino-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((4S,6S)-4-(5-amino-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

Chemical Property:

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Technology Process of N-((4S,6S)-4-(5-amino-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

There total 10 articles about N-((4S,6S)-4-(5-amino-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1624605-49-7
N-((4S,6S)-4-(5-bromo-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

: 61798-24-1,67579-81-1,68737-65-5,75599-23-4,99295-66-6,87583-89-9
(1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane

: 146-75-8,6381-77-7,6866-66-6,7317-67-1,7378-23-6,21547-69-3,58657-35-5,134-03-2
sodium L-ascorbate

: 1624603-17-3
N-((4S,6S)-4-(5-amino-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

Guidance literature:: With ammonium hydroxide; nitrogen; ammonium chloride; In ethanol; water;

Reference yield:

: 1600511-51-0
1-(5-bromo-2-fluorophenyl)-2-fluoroethan-1-one

: 1624603-17-3
N-((4S,6S)-4-(5-amino-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1: tetrahydrofuran; ethyl acetate; water

2: n-butyllithium; ammonium chloride / tetrahydrofuran; acetic acid methyl ester; [⁽²⁾H₆]acetone

3: sodium borohydrid; ammonia / tetrahydrofuran; methanol

4: sodium hydrogencarbonate / [⁽²⁾H₆]acetone

5: tetrabutyl ammonium fluoride; hydrogenchloride / tetrahydrofuran; ethyl acetate

6: hydrogenchloride / ethyl acetate; 1,4-dioxane

7: dicyclohexyl-carbodiimide; triethanolamine / tetrahydrofuran; ethyl acetate; acetonitrile

8: ammonium chloride; nitrogen; ammonium hydroxide / water; ethanol

With hydrogenchloride; ammonium hydroxide; n-butyllithium; sodium borohydrid; triethanolamine; nitrogen; ammonium chloride; tetrabutyl ammonium fluoride; ammonia; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; methanol; [⁽²⁾H₆]acetone; ethanol; acetic acid methyl ester; water; ethyl acetate; acetonitrile;

Reference yield:

: (R,E)-N-(1-(5-bromo-2-fluorophenyl)-2-fluoroethylidene)-2-methylpropane-2-sulfinamide

: 1624603-17-3
N-((4S,6S)-4-(5-amino-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: n-butyllithium; ammonium chloride / tetrahydrofuran; acetic acid methyl ester; [⁽²⁾H₆]acetone

2: sodium borohydrid; ammonia / tetrahydrofuran; methanol

3: sodium hydrogencarbonate / [⁽²⁾H₆]acetone

4: tetrabutyl ammonium fluoride; hydrogenchloride / tetrahydrofuran; ethyl acetate

5: hydrogenchloride / ethyl acetate; 1,4-dioxane

6: dicyclohexyl-carbodiimide; triethanolamine / tetrahydrofuran; ethyl acetate; acetonitrile

7: ammonium chloride; nitrogen; ammonium hydroxide / water; ethanol

With hydrogenchloride; ammonium hydroxide; n-butyllithium; sodium borohydrid; triethanolamine; nitrogen; ammonium chloride; tetrabutyl ammonium fluoride; ammonia; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; methanol; [⁽²⁾H₆]acetone; ethanol; acetic acid methyl ester; water; ethyl acetate; acetonitrile;