N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyano-2-pyridinecarboxamide

Base Information

Chemical Name:N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyano-2-pyridinecarboxamide
CAS No.:1448793-21-2
Molecular Formula:C₁₉H₁₃ClF₅N₅O₂
Molecular Weight:473.79
Hs Code.:

Synonyms:N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyano-2-pyridinecarboxamide

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Chemical Property of N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyano-2-pyridinecarboxamide

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Technology Process of N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyano-2-pyridinecarboxamide

There total 13 articles about N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyano-2-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.4%

: 1200497-81-9
3-chloro-5-cyano-pyridine-2-carboxylic acid

: 1432511-77-7
(4S,6S)-4-(5-amino-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: 1448793-21-2
N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyano-2-pyridinecarboxamide

Guidance literature:: With ammonia; In tetrahydrofuran;

Reference yield:

: 1600511-51-0
1-(5-bromo-2-fluorophenyl)-2-fluoroethan-1-one

: 1448793-21-2
N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyano-2-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 10 steps

1: tetrahydrofuran; ethyl acetate; water

2: n-butyllithium; ammonium chloride / tetrahydrofuran; acetic acid methyl ester; [⁽²⁾H₆]acetone

3: sodium borohydrid; ammonia / tetrahydrofuran; methanol

4: sodium hydrogencarbonate / [⁽²⁾H₆]acetone

5: tetrabutyl ammonium fluoride; hydrogenchloride / tetrahydrofuran; ethyl acetate

6: hydrogenchloride / ethyl acetate; 1,4-dioxane

7: dicyclohexyl-carbodiimide; triethanolamine / tetrahydrofuran; ethyl acetate; acetonitrile

8: ammonium chloride; nitrogen; ammonium hydroxide / water; ethanol

9: ethyl acetate

10: ammonia / tetrahydrofuran

With hydrogenchloride; ammonium hydroxide; n-butyllithium; sodium borohydrid; triethanolamine; nitrogen; ammonium chloride; tetrabutyl ammonium fluoride; ammonia; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; methanol; [⁽²⁾H₆]acetone; ethanol; acetic acid methyl ester; water; ethyl acetate; acetonitrile;

Reference yield:

: 1624605-44-2
(S)-methyl 3-(5-bromo-2-fluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)-4-fluorobutanoate

: 1448793-21-2
N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyano-2-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: sodium borohydrid; ammonia / tetrahydrofuran; methanol

2: sodium hydrogencarbonate / [⁽²⁾H₆]acetone

3: tetrabutyl ammonium fluoride; hydrogenchloride / tetrahydrofuran; ethyl acetate

4: hydrogenchloride / ethyl acetate; 1,4-dioxane

5: dicyclohexyl-carbodiimide; triethanolamine / tetrahydrofuran; ethyl acetate; acetonitrile

6: ammonium chloride; nitrogen; ammonium hydroxide / water; ethanol

7: ethyl acetate

8: ammonia / tetrahydrofuran

With hydrogenchloride; ammonium hydroxide; sodium borohydrid; triethanolamine; nitrogen; ammonium chloride; tetrabutyl ammonium fluoride; ammonia; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; methanol; [⁽²⁾H₆]acetone; ethanol; water; ethyl acetate; acetonitrile;