1-[4-chloro-6-cyclohexyl-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

Base Information

Chemical Name:1-[4-chloro-6-cyclohexyl-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide
CAS No.:1439923-18-8
Molecular Formula:C₂₃H₂₇ClF₃N₅O
Molecular Weight:481.948
Hs Code.:

Synonyms:1-[4-chloro-6-cyclohexyl-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

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Chemical Property of 1-[4-chloro-6-cyclohexyl-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

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Technology Process of 1-[4-chloro-6-cyclohexyl-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

There total 5 articles about 1-[4-chloro-6-cyclohexyl-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 931-50-0
cyclohexylmagnesium bromide

: 1439923-18-8
1-[4-chloro-6-cyclohexyl-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 0 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 25 °C

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.bmcl.2013.04.019

Reference yield:

: 1141894-80-5
N-[[2-(trifluoromethyl)phenyl]methyl]-4-piperidinecarboxamide

: 17419-41-9
2,4-dichloro-6-cyclohexyl-[1,3,5]triazine

: 1439923-18-8
1-[4-chloro-6-cyclohexyl-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 25 ℃; for 1h;
DOI:10.1016/j.bmcl.2013.04.019

Reference yield:

: 3048-01-9
o-trifluoromethylbenzylamine

: 1439923-18-8
1-[4-chloro-6-cyclohexyl-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 10 °C

2: trifluoroacetic acid / 1 h / 0 °C

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 25 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2013.04.019