1-[4-(methylamino)-6-cyclohexyl-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

Base Information

• Chemical Name: 1-[4-(methylamino)-6-cyclohexyl-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide
• CAS No.: 1439923-13-3
• Molecular Formula: C₂₄H₃₁F₃N₆O
• Molecular Weight: 476.545

Synonyms:1-[4-(methylamino)-6-cyclohexyl-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

Chemical Property of 1-[4-(methylamino)-6-cyclohexyl-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

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Technology Process of 1-[4-(methylamino)-6-cyclohexyl-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

There total 8 articles about 1-[4-(methylamino)-6-cyclohexyl-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

1-[4-chloro-6-methyl-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide (1141895-74-0) + dimethyl amine (124-40-3) → 1-[4-(methylamino)-6-cyclohexyl-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide (1439923-13-3)

Guidance literature:

With methanol; ammonia; N-ethyl-N,N-diisopropylamine; In water; acetonitrile; at 80 ℃;

DOI:10.1016/j.bmcl.2013.04.019

Reference yield: 59.0%

1-[4-chloro-6-cyclohexyl-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide (1439923-18-8) + methylamine (74-89-5) → 1-[4-(methylamino)-6-cyclohexyl-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide (1439923-13-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetonitrile; at 80 ℃;

DOI:10.1016/j.bmcl.2013.04.019

Reference yield:

cyclohexylmagnesium bromide (931-50-0) → 1-[4-(methylamino)-6-cyclohexyl-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide (1439923-13-3)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 0 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 25 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; acetonitrile / 80 °C

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetonitrile;

DOI:10.1016/j.bmcl.2013.04.019

upstream raw materials:

o-trifluoromethylbenzylamine

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

4-[[[[2-(trifluoromethyl)phenyl]methyl]amine]carbonyl]-1-piperidinecarboxylic acid 1,1-dimethyl-ethyl ester

N-[[2-(trifluoromethyl)phenyl]methyl]-4-piperidinecarboxamide

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