1-(2-aminoacetyl)-4-[5-(benzyloxy)pyridin-2-yl]piperazine hydrochloride

Base Information

Chemical Name:1-(2-aminoacetyl)-4-[5-(benzyloxy)pyridin-2-yl]piperazine hydrochloride
CAS No.:1322094-89-2
Molecular Formula:C₁₈H₂₂N₄O₂*ClH
Molecular Weight:362.859
Hs Code.:

Synonyms:1-(2-aminoacetyl)-4-[5-(benzyloxy)pyridin-2-yl]piperazine hydrochloride

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Chemical Property of 1-(2-aminoacetyl)-4-[5-(benzyloxy)pyridin-2-yl]piperazine hydrochloride

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Technology Process of 1-(2-aminoacetyl)-4-[5-(benzyloxy)pyridin-2-yl]piperazine hydrochloride

There total 5 articles about 1-(2-aminoacetyl)-4-[5-(benzyloxy)pyridin-2-yl]piperazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1215855-70-1
tert-butyl N-{2-[4-(5-(benzyloxy)pyridin-2-yl)piperazin-1-yl]-2-oxoethyl}carbamate

: 1322094-89-2
1-(2-aminoacetyl)-4-[5-(benzyloxy)pyridin-2-yl]piperazine hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; at 20 ℃; Product distribution / selectivity;

Reference yield:

: 630120-99-9
5-(benzyloxy)-2-bromopyridine

: 1322094-89-2
1-(2-aminoacetyl)-4-[5-(benzyloxy)pyridin-2-yl]piperazine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene; tetrahydrofuran / 20 °C / Reflux

2: dichloromethane; tetrahydrofuran / -10 - 20 °C

3: hydrogenchloride / diethyl ether / 20 °C

With hydrogenchloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;

Reference yield:

: 100-39-0
benzyl bromide

: 1322094-89-2
1-(2-aminoacetyl)-4-[5-(benzyloxy)pyridin-2-yl]piperazine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 - 60 °C

2: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene; tetrahydrofuran / 20 °C / Reflux

3: dichloromethane; tetrahydrofuran / -10 - 20 °C

4: hydrogenchloride / diethyl ether / 20 °C

With hydrogenchloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;