furo[2,3-c]pyridine-2-carboxylic acid 4-(1-isobutylpiperidine-4-sulfinyl)benzylamide

Base Information

Chemical Name:furo[2,3-c]pyridine-2-carboxylic acid 4-(1-isobutylpiperidine-4-sulfinyl)benzylamide
CAS No.:1453175-37-5
Molecular Formula:C₂₄H₂₉N₃O₃S
Molecular Weight:439.579
Hs Code.:

Synonyms:furo[2,3-c]pyridine-2-carboxylic acid 4-(1-isobutylpiperidine-4-sulfinyl)benzylamide

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Chemical Property of furo[2,3-c]pyridine-2-carboxylic acid 4-(1-isobutylpiperidine-4-sulfinyl)benzylamide

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Technology Process of furo[2,3-c]pyridine-2-carboxylic acid 4-(1-isobutylpiperidine-4-sulfinyl)benzylamide

There total 15 articles about furo[2,3-c]pyridine-2-carboxylic acid 4-(1-isobutylpiperidine-4-sulfinyl)benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 1453176-83-4
4-(1-isobutylpiperidine-4-sulfinyl)benzylamine

: 112372-15-3
furo<2,3-c>pyridine-2-carboxylic acid

: 1453175-37-5
furo[2,3-c]pyridine-2-carboxylic acid 4-(1-isobutylpiperidine-4-sulfinyl)benzylamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Reference yield:

: 188527-03-9
4-(4-bromophenylsulfanyl)piperidine-1-carboxylic acid tert-butyl ester

: 1453175-37-5
furo[2,3-c]pyridine-2-carboxylic acid 4-(1-isobutylpiperidine-4-sulfinyl)benzylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid; dihydrogen peroxide / dichloromethane; isopropyl alcohol / 2 h / 50 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere

3.1: thionyl chloride / methanol / 0.5 h / 0 - 20 °C

4.1: acetic acid; titanium(IV) isopropylate / ethanol / 2 h / 60 °C

4.2: 1 h / 60 °C

5.1: hydrogen / methanol / 0.5 h / 20 °C / 760.05 Torr

6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

With titanium(IV) isopropylate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; thionyl chloride; sulfuric acid; hydrogen; dihydrogen peroxide; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1453176-80-1
4-(4-cyanobenzenesulfinyl)piperidine-1-carboxylic acid tert-butyl ester

: 1453175-37-5
furo[2,3-c]pyridine-2-carboxylic acid 4-(1-isobutylpiperidine-4-sulfinyl)benzylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / methanol / 0.5 h / 0 - 20 °C

2.1: acetic acid; titanium(IV) isopropylate / ethanol / 2 h / 60 °C

2.2: 1 h / 60 °C

3.1: hydrogen / methanol / 0.5 h / 20 °C / 760.05 Torr

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

With titanium(IV) isopropylate; thionyl chloride; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; N,N-dimethyl-formamide;