188527-03-9

Usage

Uses

Used in Organic Chemistry:
Tert-butyl 4-(4-bromophenylthio)piperidine-1-carboxylate is used as a synthetic intermediate for the preparation of various organic compounds. Its unique structure allows for versatile chemical reactions, making it a valuable building block in organic synthesis.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, tert-butyl 4-(4-bromophenylthio)piperidine-1-carboxylate is used as a precursor in the synthesis of bioactive molecules and drug candidates. Its presence in the molecule can impart specific pharmacological properties, contributing to the development of new therapeutic agents.
Used in Agrochemicals:
Tert-butyl 4-(4-bromophenylthio)piperidine-1-carboxylate is also utilized in the agrochemical sector as an intermediate for the synthesis of agrochemical products. Its chemical properties can be harnessed to create compounds with pesticidal or herbicidal activities, contributing to crop protection and yield enhancement.

Upstream product

• 106-53-6 para-bromobenzenethiol 
• 141699-59-4 1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 911410-37-2 1-(4-hydroxypiperidin-1-yl)-2,2-dimethylpropan-1-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 5382-16-1 4-HYDROXYPIPERIDINE 

Downstream Products

• 226398-62-5 4-(4-bromobenzenesulfonyl)piperidine-1-carboxylic acid tert-butyl ester 
• 797750-44-8 4-(4-cyanobenzenesulfonyl)piperidine-1-carboxylic acid tert-butyl ester 
• 1450723-99-5 C₁₂H₁₄N₂O₂S 
• 1450724-00-1 4-(1-acetylpiperidine-4-sulfonyl)benzonitrile 
• 1450724-01-2 C₁₅H₁₈N₂O₃S 
• 1450724-04-5 C₁₅H₁₈N₂O₃S 
• 1450724-05-6 4-[1-(tetrahydropyran-4-yl)piperidine-4-sulfonyl]benzonitrile 
• 1450724-02-3 C₁₃H₁₆N₂O₂S 
• 1450724-03-4 C₁₅H₂₀N₂O₂S 
• 1450723-87-1 C₁₃H₂₀N₂O₂S 
• 1450723-88-2 C₁₅H₂₄N₂O₂S 
• 1450723-34-8 N-[[4-(4,4-difluorocyclohexyl)sulfonylphenyl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide 
• 1450724-22-7 C₂₀H₂₃N₃O₆S 
• 1450724-23-8 C₂₂H₂₇N₃O₆S 

Relevant academic research and scientific papers

Synthesis and Characterization of N-(4-(Piperidin-4-ylsulfonyl) phenyl)5-vinylpyrimidin-2-amine

Target product N-(4-(piperidin-4-ylsulfonyl)phenyl)5-vinylpyrimidin-2- amine (13) was synthesized using 6-oxopyran-3-carbaldehyde (M1) and 4-hydroxypiperidine (M2) as starting materials by a series of nucleophilic substitution and oxidation. Different aci

Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility

Herein we report the optimization efforts to ameliorate the potent CYP3A4 time-dependent inhibition (TDI) and low aqueous solubility exhibited by a previously identified lead compound from our NAMPT inhibitor program (1, GNE-617). Metabolite identification studies pinpointed the imidazopyridine moiety present in 1 as the likely source of the TDI signal, and replacement with other bicyclic systems was found to reduce or eliminate the TDI finding. A strategy of reducing the number of aromatic rings and/or lowering c Log D7.4 was then employed to significantly improve aqueous solubility. These efforts culminated in the discovery of 42, a compound with no evidence of TDI, improved aqueous solubility, and robust efficacy in tumor xenograft studies.

AMIDO-BENZYL SULFONE AND SULFOXIDE DERIVATIVES

The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitors containing 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas were identified using structure-based design techniques. The new compounds displayed improved aqueous solubilities, determined using a high-throughput solubility assessment, relative to previously disclosed urea and amide-containing NAMPT inhibitors. An optimized 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived compound exhibited potent anti-NAMPT activity (18; BC NAMPT IC50 = 11 nM; PC-3 antiproliferative IC50 = 36 nM), satisfactory mouse PK properties, and was efficacious in a PC-3 mouse xenograft model. The crystal structure of another optimized compound (29; NAMPT IC50 = 10 nM; A2780 antiproliferative IC50 = 7 nM) in complex with the NAMPT protein was also determined.

THIAZOLE INHIBITORS TARGETING RESISTANT AND KINASE MUTATIONS

A compound is provided, having the general structure (A): wherein A is an aryl or heteroaryl group, Y is a hydrophobic linking moiety, and L is a substitutent. The compound (A) can be used for treatment of various angiogenic-associated or hematologic disorders, such as myeloproliferative disorders in patients who do not respond to kinase-inhibition therapy that comprises administering currently used medications.

Phenylsulphonyl derivatives as 5-HT receptor ligands

A class of phenylsulphonyl derivatives wherein the sulphonyl moiety is also attached to an N-arylalkyl-substituted azetidine, pyrrolidine or piperidine ring are selective antagonists of the human 5-HT2Areceptor and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of adverse conditions of the central nervous system, including schizophrenia and depression.

4-(Phenylsulfonyl)piperidines: Novel, selective, and bioavailable 5-HT2A receptor antagonists

On the basis of a spirocyclic ether screening lead, a series of acyclic sulfones have been identifed as high-affinity, selective 5-HT2A receptor antagonists. Bioavailability lacking in the parent, 1-(2-(2,4-difluorophenyl)ethyl)-4-(phenylsulfon