cytidin-5'-yl 5-N-carbobenzyloxyamino-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulopyranosid-2''-yl phosphate

Base Information

Chemical Name:cytidin-5'-yl 5-N-carbobenzyloxyamino-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulopyranosid-2''-yl phosphate
CAS No.:135546-48-4
Molecular Formula:C₂₆H₃₅N₄O₁₇P
Molecular Weight:706.554
Hs Code.:

Synonyms:cytidin-5'-yl 5-N-carbobenzyloxyamino-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulopyranosid-2''-yl phosphate

Suppliers and Price of cytidin-5'-yl 5-N-carbobenzyloxyamino-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulopyranosid-2''-yl phosphate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of cytidin-5'-yl 5-N-carbobenzyloxyamino-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulopyranosid-2''-yl phosphate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of cytidin-5'-yl 5-N-carbobenzyloxyamino-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulopyranosid-2''-yl phosphate

There total 13 articles about cytidin-5'-yl 5-N-carbobenzyloxyamino-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulopyranosid-2''-yl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 145552-07-4
5-N-carbobenzoxylamino-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulopyranosidonic acid

: 65-47-4,13191-15-6
cytidine triphosphate

: 135546-48-4
cytidin-5'-yl 5-N-carbobenzyloxyamino-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulopyranosid-2''-yl phosphate

Guidance literature:: With inorganic pyrophosphatase (EC 3.6.1.1); Neisseria meningitidis B; recombinant CMP-sialate synthetase; magnesium chloride; In water; at 20 ℃; pH=8.5; Enzymatic reaction;
DOI:10.1002/1615-4169(200108)343:6/7<698::AID-ADSC698>3.0.CO;2-J

Reference yield:

: 146669-04-7
2,4,7,8,9-penta-O-acetyl-5-N-carbobenzoxylamino-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulo-pyranosidonic acid methyl ester

: 135546-48-4
cytidin-5'-yl 5-N-carbobenzyloxyamino-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulopyranosid-2''-yl phosphate

Guidance literature:: Multi-step reaction with 7 steps

1: conc. HCl, AcCl / CH₂Cl₂ / 65 h

2: Ag₂CO₃ / acetone; H₂O / 48 h

3: 43 percent / Et₃N / acetonitrile / -43 deg C -> room temperature

4: Et₃N, t-BuOOH / acetonitrile / 1 h / Ambient temperature

5: iPr₂NH, (Ph₃P)4Pd / acetonitrile / 0.5 h

6: NaOMe / methanol / 0.5 h

7: aq. NaOH / 0.17 h

With hydrogenchloride; tert.-butylhydroperoxide; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; triethylamine; diisopropylamine; acetyl chloride; silver carbonate; In methanol; dichloromethane; water; acetone; acetonitrile;
DOI:10.1016/S0040-4020(97)00370-0

Reference yield:

: 58479-65-5
5'-O-(tert-butyldiphenylsilyl)cytidine

: 135546-48-4
cytidin-5'-yl 5-N-carbobenzyloxyamino-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulopyranosid-2''-yl phosphate

Guidance literature:: Multi-step reaction with 8 steps

1: pyridine / 12 h

2: 94 percent / n-Bu₄NF, AcOH / tetrahydrofuran / 18 h / Ambient temperature

3: 61 percent / diisopropylammoniumtetrazole / CH₂Cl₂ / 2 h

4: 43 percent / Et₃N / acetonitrile / -43 deg C -> room temperature

5: Et₃N, t-BuOOH / acetonitrile / 1 h / Ambient temperature

6: iPr₂NH, (Ph₃P)4Pd / acetonitrile / 0.5 h

7: NaOMe / methanol / 0.5 h

8: aq. NaOH / 0.17 h

With tert.-butylhydroperoxide; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-diisopropylamine tetrazolide; tetrabutyl ammonium fluoride; sodium methylate; acetic acid; triethylamine; diisopropylamine; In tetrahydrofuran; pyridine; methanol; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4020(97)00370-0