5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(isobutyl(methyl)amino)-2-methylbenzamide

Base Information

Chemical Name:5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(isobutyl(methyl)amino)-2-methylbenzamide
CAS No.:1403591-25-2
Molecular Formula:C₂₁H₂₈ClN₃O₂
Molecular Weight:389.925
Hs Code.:

Synonyms:5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(isobutyl(methyl)amino)-2-methylbenzamide

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Chemical Property of 5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(isobutyl(methyl)amino)-2-methylbenzamide

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Technology Process of 5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(isobutyl(methyl)amino)-2-methylbenzamide

There total 7 articles about 5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(isobutyl(methyl)amino)-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 771579-27-2
3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one

: 1403596-62-2
C₁₃H₁₈ClNO₂

: 1403591-25-2
5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(isobutyl(methyl)amino)-2-methylbenzamide

Guidance literature:: 3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one; C₁₃H₁₈ClNO₂; In dimethyl sulfoxide; at 20 ℃; for 15h;

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In dimethyl sulfoxide;

Reference yield:

: 294190-17-3
methyl 5-chloro-2-methyl-3-nitrobenzoate

: 1403591-25-2
5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(isobutyl(methyl)amino)-2-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; ammonium chloride; iron / ethanol / 1 h / 80 °C

2.1: acetic acid / methanol / 2 h / 20 °C

2.2: 0 - 20 °C

3.1: caesium carbonate / acetonitrile / 12 h / 80 °C

4.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

4.2: pH 4 - 6

5.1: dimethyl sulfoxide / 15 h / 20 °C

With water; iron; ammonium chloride; caesium carbonate; acetic acid; sodium hydroxide; In methanol; ethanol; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 294190-18-4
methyl 3-amino-5-chloro-2-methylbenzoate

: 1403591-25-2
5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(isobutyl(methyl)amino)-2-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / methanol / 2 h / 20 °C

1.2: 0 - 20 °C

2.1: caesium carbonate / acetonitrile / 12 h / 80 °C

3.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

3.2: pH 4 - 6

4.1: dimethyl sulfoxide / 15 h / 20 °C

With water; caesium carbonate; acetic acid; sodium hydroxide; In methanol; ethanol; dimethyl sulfoxide; acetonitrile;