(+/-)-1,4,5,6-tetrahydro-4-(3-methoxyphenyl)-N,N,1-trimethyl-4-propyl-3-pyridinemethaneamine

Base Information

Chemical Name:(+/-)-1,4,5,6-tetrahydro-4-(3-methoxyphenyl)-N,N,1-trimethyl-4-propyl-3-pyridinemethaneamine
CAS No.:97966-11-5
Molecular Formula:C₁₉H₃₀N₂O
Molecular Weight:302.46
Hs Code.:

Synonyms:(+/-)-1,4,5,6-tetrahydro-4-(3-methoxyphenyl)-N,N,1-trimethyl-4-propyl-3-pyridinemethaneamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-1,4,5,6-tetrahydro-4-(3-methoxyphenyl)-N,N,1-trimethyl-4-propyl-3-pyridinemethaneamine

Chemical Property:

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Technology Process of (+/-)-1,4,5,6-tetrahydro-4-(3-methoxyphenyl)-N,N,1-trimethyl-4-propyl-3-pyridinemethaneamine

There total 7 articles about (+/-)-1,4,5,6-tetrahydro-4-(3-methoxyphenyl)-N,N,1-trimethyl-4-propyl-3-pyridinemethaneamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 97966-10-4
1,2,3,4-tetrahydro-4-(3-methoxyphenyl)-1-methyl-4-propylpyridine

: 124-40-3
dimethyl amine

: 97966-11-5
(+/-)-1,4,5,6-tetrahydro-4-(3-methoxyphenyl)-N,N,1-trimethyl-4-propyl-3-pyridinemethaneamine

Guidance literature:: With sulfuric acid; In water; at 65 - 70 ℃; for 2h; pH 3-3.5;
DOI:10.1021/jo00281a019

Reference yield:

aqueous dimethylamine: aqueous dimethylamine

: 1,2,3,4-tetrahydro-4-(3-methoxyphenyl)-1-methyl-4-propylpyridine sulfate

: 97966-10-4
1,2,3,4-tetrahydro-4-(3-methoxyphenyl)-1-methyl-4-propylpyridine

: 97966-11-5
(+/-)-1,4,5,6-tetrahydro-4-(3-methoxyphenyl)-N,N,1-trimethyl-4-propyl-3-pyridinemethaneamine

Guidance literature:: With sodium hydroxide; formaldehyd; sulfuric acid; In hexane; water;

Reference yield:

: 1445-73-4
1-Methyl-4-piperidone

: 97966-11-5
(+/-)-1,4,5,6-tetrahydro-4-(3-methoxyphenyl)-N,N,1-trimethyl-4-propyl-3-pyridinemethaneamine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) sec-butyllithium / 1.)THF, cyclohexane, -50 deg C, 1 h, 2.) -20 deg C, 1,5 h, RT, 1 h

2: p-toluenesulfonic acid monohydrate / toluene / 2 h / Heating; azeotropic separation of water

3: 1.) n-butyllithium / 1.) THF, hexane, -5 deg C, 15 min, THF/hexane, 2.) -5 deg C, 10 min

4: CH₂Cl₂ / 2.5 h / Ambient temperature

With n-butyllithium; sec.-butyllithium; toluene-4-sulfonic acid; In dichloromethane; toluene;
DOI:10.1021/jo00281a019