(2S)-{3-[2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylvinylsilane

Base Information

Chemical Name:(2S)-{3-[2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylvinylsilane
CAS No.:915769-88-9
Molecular Formula:C₂₇H₃₄O₄Si
Molecular Weight:450.65
Hs Code.:

Synonyms:(2S)-{3-[2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylvinylsilane

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Chemical Property of (2S)-{3-[2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylvinylsilane

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Technology Process of (2S)-{3-[2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylvinylsilane

There total 9 articles about (2S)-{3-[2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylvinylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 915769-87-8
3-[(2S)-2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]-2-bromofuran

: 1719-58-0
Chlorodimethylvinylsilane

: 915769-88-9
(2S)-{3-[2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylvinylsilane

Guidance literature:: 3-[(2S)-2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]-2-bromofuran; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.416667h;

Chlorodimethylvinylsilane; In tetrahydrofuran; at -78 ℃; for 0.416667h; Further stages.;
DOI:10.1016/j.tet.2007.04.031

Reference yield:

: 169310-73-0
1-methoxy-4-((3-methylbut-3-en-1-yl)oxy)benzene

: 915769-88-9
(2S)-{3-[2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylvinylsilane

Guidance literature:: Multi-step reaction with 6 steps

1.1: 95 percent / K₂OsO₂(OH)4; K₂CO₃; DHQ₂PHAL / K₃Fe(CN)6 / 2-methyl-propan-2-ol; H₂O / 24 h / 0 °C

2.1: 90 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 48 h / 20 °C

3.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

3.2: 84 percent / BF₃*Et₂O / tetrahydrofuran; hexane / 1 h / -78 °C

4.1: 100 percent / KH / dimethylformamide / 0.75 h / 0 °C

5.1: 86 percent / N-bromosuccinimide / dimethylformamide / 1 h / 0 °C

6.1: n-BuLi / tetrahydrofuran / 0.42 h / -78 °C

6.2: 88 percent / tetrahydrofuran / 0.42 h / -78 °C

With dmap; N-Bromosuccinimide; n-butyllithium; potassium dioxotetrahydroxoosmate(VI); potassium hydride; potassium carbonate; hydroquinidein 1,4-phthalazinediyl diether; triethylamine; potassium hexacyanoferrate(III); In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1.1: Sharpless asymmetric dihydroxylation;
DOI:10.1016/j.tet.2007.04.031

Reference yield:

: 209118-78-5
(2S)-4-(4-methoxyphenoxy)-2-methylbutane-1,2-diol

: 915769-88-9
(2S)-{3-[2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylvinylsilane

Guidance literature:: Multi-step reaction with 5 steps

1.1: 90 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 48 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

2.2: 84 percent / BF₃*Et₂O / tetrahydrofuran; hexane / 1 h / -78 °C

3.1: 100 percent / KH / dimethylformamide / 0.75 h / 0 °C

4.1: 86 percent / N-bromosuccinimide / dimethylformamide / 1 h / 0 °C

5.1: n-BuLi / tetrahydrofuran / 0.42 h / -78 °C

5.2: 88 percent / tetrahydrofuran / 0.42 h / -78 °C

With dmap; N-Bromosuccinimide; n-butyllithium; potassium hydride; triethylamine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2007.04.031