(2S)-2-({3-[2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylsilanyl)ethanol

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Chemical Name:(2S)-2-({3-[2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylsilanyl)ethanol
CAS No.:915769-83-4
Molecular Formula:C₂₇H₃₆O₅Si
Molecular Weight:468.665
Hs Code.:

Synonyms:(2S)-2-({3-[2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylsilanyl)ethanol

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Chemical Property of (2S)-2-({3-[2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylsilanyl)ethanol

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Technology Process of (2S)-2-({3-[2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylsilanyl)ethanol

There total 11 articles about (2S)-2-({3-[2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylsilanyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 915769-88-9
(2S)-{3-[2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylvinylsilane

: 915769-83-4
(2S)-2-({3-[2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylsilanyl)ethanol

Guidance literature:: (2S)-{3-[2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylvinylsilane; With 9-borabicyclo[3.3.1]nonane dimer; In tetrahydrofuran; at 20 ℃; for 3h;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; at 0 ℃; for 0.5h; Further stages.;
DOI:10.1016/j.tet.2007.04.031

Reference yield:

: 169310-73-0
1-methoxy-4-((3-methylbut-3-en-1-yl)oxy)benzene

: 915769-83-4
(2S)-2-({3-[2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylsilanyl)ethanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: 95 percent / K₂OsO₂(OH)4; K₂CO₃; DHQ₂PHAL / K₃Fe(CN)6 / 2-methyl-propan-2-ol; H₂O / 24 h / 0 °C

2.1: 90 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 48 h / 20 °C

3.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

3.2: 84 percent / BF₃*Et₂O / tetrahydrofuran; hexane / 1 h / -78 °C

4.1: 100 percent / KH / dimethylformamide / 0.75 h / 0 °C

5.1: 86 percent / N-bromosuccinimide / dimethylformamide / 1 h / 0 °C

6.1: n-BuLi / tetrahydrofuran / 0.42 h / -78 °C

6.2: 88 percent / tetrahydrofuran / 0.42 h / -78 °C

7.1: 9-BBN / tetrahydrofuran / 3 h / 20 °C

7.2: 96 percent / aq. NaOH; aq. H₂O₂ / tetrahydrofuran / 0.5 h / 0 °C

With dmap; N-Bromosuccinimide; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; potassium dioxotetrahydroxoosmate(VI); potassium hydride; potassium carbonate; hydroquinidein 1,4-phthalazinediyl diether; triethylamine; potassium hexacyanoferrate(III); In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1.1: Sharpless asymmetric dihydroxylation;
DOI:10.1016/j.tet.2007.04.031

Reference yield:

: 209118-78-5
(2S)-4-(4-methoxyphenoxy)-2-methylbutane-1,2-diol

: 915769-83-4
(2S)-2-({3-[2-benzyloxy-4-(4-methoxyphenoxy)-2-methylbutyl]furan-2-yl}dimethylsilanyl)ethanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 90 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 48 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

2.2: 84 percent / BF₃*Et₂O / tetrahydrofuran; hexane / 1 h / -78 °C

3.1: 100 percent / KH / dimethylformamide / 0.75 h / 0 °C

4.1: 86 percent / N-bromosuccinimide / dimethylformamide / 1 h / 0 °C

5.1: n-BuLi / tetrahydrofuran / 0.42 h / -78 °C

5.2: 88 percent / tetrahydrofuran / 0.42 h / -78 °C

6.1: 9-BBN / tetrahydrofuran / 3 h / 20 °C

6.2: 96 percent / aq. NaOH; aq. H₂O₂ / tetrahydrofuran / 0.5 h / 0 °C

With dmap; N-Bromosuccinimide; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; potassium hydride; triethylamine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2007.04.031