2-(3-hydroxyphenyl)-1-[5-(3-hydroxyphenyl)thiophen-2-yl]-2-methylpropan-1-one

Base Information

Chemical Name:2-(3-hydroxyphenyl)-1-[5-(3-hydroxyphenyl)thiophen-2-yl]-2-methylpropan-1-one
CAS No.:1620518-38-8
Molecular Formula:C₂₀H₁₈O₃S
Molecular Weight:338.427
Hs Code.:

Synonyms:2-(3-hydroxyphenyl)-1-[5-(3-hydroxyphenyl)thiophen-2-yl]-2-methylpropan-1-one

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Chemical Property of 2-(3-hydroxyphenyl)-1-[5-(3-hydroxyphenyl)thiophen-2-yl]-2-methylpropan-1-one

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Technology Process of 2-(3-hydroxyphenyl)-1-[5-(3-hydroxyphenyl)thiophen-2-yl]-2-methylpropan-1-one

There total 5 articles about 2-(3-hydroxyphenyl)-1-[5-(3-hydroxyphenyl)thiophen-2-yl]-2-methylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1620518-37-7
2-(3-methoxyphenyl)-1-[5-(3-methoxyphenyl)thiophen-2-yl]-2-methylpropan-1-one

: 1620518-38-8
2-(3-hydroxyphenyl)-1-[5-(3-hydroxyphenyl)thiophen-2-yl]-2-methylpropan-1-one

Guidance literature:: With boron dimethyl-trifluoro sulphide; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.ejmech.2014.06.036

Reference yield:

: 17653-94-0
α-methyl-α-(3-methoxyphenyl)proprionic acid

: 1620518-38-8
2-(3-hydroxyphenyl)-1-[5-(3-hydroxyphenyl)thiophen-2-yl]-2-methylpropan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride; N,N-dimethyl-formamide / toluene / 4 h / Reflux

2: aluminum (III) chloride / dichloromethane / -20 - 20 °C / Inert atmosphere

3: boron dimethyl-trifluoro sulphide / dichloromethane / 0 - 20 °C

With aluminum (III) chloride; thionyl chloride; boron dimethyl-trifluoro sulphide; N,N-dimethyl-formamide; In dichloromethane; toluene; 2: |Friedel-Crafts Acylation;
DOI:10.1016/j.ejmech.2014.06.036

Reference yield:

: 17653-93-9
2-(3'-Methoxyphenyl)-2-methylpropionitrile

: 1620518-38-8
2-(3-hydroxyphenyl)-1-[5-(3-hydroxyphenyl)thiophen-2-yl]-2-methylpropan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide / ethylene glycol / 150 °C

2: thionyl chloride; N,N-dimethyl-formamide / toluene / 4 h / Reflux

3: aluminum (III) chloride / dichloromethane / -20 - 20 °C / Inert atmosphere

4: boron dimethyl-trifluoro sulphide / dichloromethane / 0 - 20 °C

With aluminum (III) chloride; thionyl chloride; boron dimethyl-trifluoro sulphide; N,N-dimethyl-formamide; potassium hydroxide; In dichloromethane; ethylene glycol; toluene; 3: |Friedel-Crafts Acylation;
DOI:10.1016/j.ejmech.2014.06.036