2-(3-methoxyphenyl)-1-[5-(3-methoxyphenyl)thiophen-2-yl]-2-methylpropan-1-one

Base Information

Chemical Name:2-(3-methoxyphenyl)-1-[5-(3-methoxyphenyl)thiophen-2-yl]-2-methylpropan-1-one
CAS No.:1620518-37-7
Molecular Formula:C₂₂H₂₂O₃S
Molecular Weight:366.481
Hs Code.:

Synonyms:2-(3-methoxyphenyl)-1-[5-(3-methoxyphenyl)thiophen-2-yl]-2-methylpropan-1-one

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Chemical Property of 2-(3-methoxyphenyl)-1-[5-(3-methoxyphenyl)thiophen-2-yl]-2-methylpropan-1-one

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Technology Process of 2-(3-methoxyphenyl)-1-[5-(3-methoxyphenyl)thiophen-2-yl]-2-methylpropan-1-one

There total 4 articles about 2-(3-methoxyphenyl)-1-[5-(3-methoxyphenyl)thiophen-2-yl]-2-methylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 17595-93-6
2-(3-methoxyphenyl)thiophene

: α-methyl-α-(3-methoxyphenyl)proprionic acid chloride

: 1620518-37-7
2-(3-methoxyphenyl)-1-[5-(3-methoxyphenyl)thiophen-2-yl]-2-methylpropan-1-one

Guidance literature:: With aluminum (III) chloride; In dichloromethane; at -20 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.06.036

Reference yield:

: 17653-93-9
2-(3'-Methoxyphenyl)-2-methylpropionitrile

: 1620518-37-7
2-(3-methoxyphenyl)-1-[5-(3-methoxyphenyl)thiophen-2-yl]-2-methylpropan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / ethylene glycol / 150 °C

2: thionyl chloride; N,N-dimethyl-formamide / toluene / 4 h / Reflux

3: aluminum (III) chloride / dichloromethane / -20 - 20 °C / Inert atmosphere

With aluminum (III) chloride; thionyl chloride; N,N-dimethyl-formamide; potassium hydroxide; In dichloromethane; ethylene glycol; toluene; 3: |Friedel-Crafts Acylation;
DOI:10.1016/j.ejmech.2014.06.036

Reference yield:

: 17653-94-0
α-methyl-α-(3-methoxyphenyl)proprionic acid

: 1620518-37-7
2-(3-methoxyphenyl)-1-[5-(3-methoxyphenyl)thiophen-2-yl]-2-methylpropan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / toluene / 4 h / Reflux

2: aluminum (III) chloride / dichloromethane / -20 - 20 °C / Inert atmosphere

With aluminum (III) chloride; thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; toluene; 2: |Friedel-Crafts Acylation;
DOI:10.1016/j.ejmech.2014.06.036