C₃₁H₃₈Cl₂F₂N₄OSi

Base Information

Chemical Name:C₃₁H₃₈Cl₂F₂N₄OSi
CAS No.:1350325-39-1
Molecular Formula:C₃₁H₃₈Cl₂F₂N₄OSi
Molecular Weight:619.657
Hs Code.:

C<sub>31</sub>H<sub>38</sub>Cl<sub>2</sub>F<sub>2</sub>N<sub>4</sub>OSi

Synonyms:C₃₁H₃₈Cl₂F₂N₄OSi

Suppliers and Price of C₃₁H₃₈Cl₂F₂N₄OSi

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₃₁H₃₈Cl₂F₂N₄OSi

Chemical Property:

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Technology Process of C₃₁H₃₈Cl₂F₂N₄OSi

There total 17 articles about C₃₁H₃₈Cl₂F₂N₄OSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350325-37-9
5-[1-(trans-4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-5-methyl-1H-pyrazol-4-yl]-3-[1-(2,6-dichloro-3-fluorophenyl)-2-fluoro-2,2-bis(phenylsulfonyl)ethyl]-1H-pyrrolo[2,3-b]pyridine

: 1350325-39-1
C₃₁H₃₈Cl₂F₂N₄OSi

Guidance literature:: With methanol; disodium hydrogenphosphate; In tetrahydrofuran; at -20 - -5 ℃; for 1.5h;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1350325-39-1
C₃₁H₃₈Cl₂F₂N₄OSi

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap; 1H-imidazole / dichloromethane / 0.33 h / 20 °C

2.1: lithium diisopropyl amide / cyclohexane; tetrahydrofuran / 0.08 h / -78 °C

2.2: 0.5 h / -78 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 20 °C

3.2: 1 h / 20 °C

4.1: potassium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1.5 h / 90 °C / Inert atmosphere

5.1: disodium hydrogenphosphate; methanol / tetrahydrofuran / 1.5 h / -20 - -5 °C

With 1H-imidazole; methanol; dmap; potassium fluoride; disodium hydrogenphosphate; isopropylmagnesium chloride; lithium diisopropyl amide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; cyclohexane; water;

Reference yield:

: 178813-77-9
2,6-dichloro-3-fluorobenzaldehyde

: 1350325-39-1
C₃₁H₃₈Cl₂F₂N₄OSi

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / methanol / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: 1 h / -78 - 20 °C

3.1: potassium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1.5 h / 90 °C / Inert atmosphere

4.1: disodium hydrogenphosphate; methanol / tetrahydrofuran / 1.5 h / -20 - -5 °C

With methanol; potassium fluoride; disodium hydrogenphosphate; n-butyllithium; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water;