ethyl 4-(tert-butoxycarbonyl(2,4-dimethoxybenzyl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxylate

Base Information

Chemical Name:ethyl 4-(tert-butoxycarbonyl(2,4-dimethoxybenzyl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxylate
CAS No.:1271024-59-9
Molecular Formula:C₂₈H₃₅N₅O₆
Molecular Weight:537.616
Hs Code.:

Synonyms:ethyl 4-(tert-butoxycarbonyl(2,4-dimethoxybenzyl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxylate

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Chemical Property of ethyl 4-(tert-butoxycarbonyl(2,4-dimethoxybenzyl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxylate

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Technology Process of ethyl 4-(tert-butoxycarbonyl(2,4-dimethoxybenzyl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxylate

There total 8 articles about ethyl 4-(tert-butoxycarbonyl(2,4-dimethoxybenzyl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1271024-57-7
ethyl 4-(tert-butoxycarbonyl(2,4-dimethoxybenzyl)amino)-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxylate

: 75-03-6
ethyl iodide

: 1271024-59-9
ethyl 4-(tert-butoxycarbonyl(2,4-dimethoxybenzyl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 1h;

Reference yield:

: 20781-20-8
2,4-Dimethoxybenzylamine

: 1271024-59-9
ethyl 4-(tert-butoxycarbonyl(2,4-dimethoxybenzyl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 3 h / 110 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / -78 °C

2.2: -78 - 20 °C

3.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 90 °C

4.1: hydrogenchloride / water; tetrahydrofuran / 0.03 h

5.1: N-iodo-succinimide / acetonitrile / 0.83 h / 0 °C

6.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ISOPROPYLAMIDE / 6 h / 60 °C / Inert atmosphere

7.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

With hydrogenchloride; N-iodo-succinimide; sodium hexamethyldisilazane; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1271024-44-2
tert-butyl 6-chloro-1-methyl-1H-imidazo[4.5-c]pyridin-4-yl(2,4-dimethoxybenzyl)carbamate

: 1271024-59-9
ethyl 4-(tert-butoxycarbonyl(2,4-dimethoxybenzyl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 90 °C

2: hydrogenchloride / water; tetrahydrofuran / 0.03 h

3: N-iodo-succinimide / acetonitrile / 0.83 h / 0 °C

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ISOPROPYLAMIDE / 6 h / 60 °C / Inert atmosphere

5: caesium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

With hydrogenchloride; N-iodo-succinimide; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; acetonitrile;