N-[3-cyano-4-[[(1E)-(dimethylamino)methylene]amino]phenyl]-N'-(2-hydroxy-1,1-dimethylethyl)thiourea

Base Information

Chemical Name:N-[3-cyano-4-[[(1E)-(dimethylamino)methylene]amino]phenyl]-N'-(2-hydroxy-1,1-dimethylethyl)thiourea
CAS No.:1429755-57-6
Molecular Formula:C₁₅H₂₁N₅OS
Molecular Weight:319.431
Hs Code.:

Synonyms:N-[3-cyano-4-[[(1E)-(dimethylamino)methylene]amino]phenyl]-N'-(2-hydroxy-1,1-dimethylethyl)thiourea

Suppliers and Price of N-[3-cyano-4-[[(1E)-(dimethylamino)methylene]amino]phenyl]-N'-(2-hydroxy-1,1-dimethylethyl)thiourea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Chemenu
(E)-N''-(2-cyano-4-(3-(1-hydroxy-2-methylpropan-2-yl)thioureido)phenyl)-N,N-dimethylformimidamide 95%+
1000g
$ 22080.00

Total 9 raw suppliers

Chemical Property of N-[3-cyano-4-[[(1E)-(dimethylamino)methylene]amino]phenyl]-N'-(2-hydroxy-1,1-dimethylethyl)thiourea

Chemical Property:

Density:1.24 at 20℃

Purity/Quality:

99%, ^*data from raw suppliers

(E)-N''-(2-cyano-4-(3-(1-hydroxy-2-methylpropan-2-yl)thioureido)phenyl)-N,N-dimethylformimidamide 95%+ ^*data from reagent suppliers

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Technology Process of N-[3-cyano-4-[[(1E)-(dimethylamino)methylene]amino]phenyl]-N'-(2-hydroxy-1,1-dimethylethyl)thiourea

There total 4 articles about N-[3-cyano-4-[[(1E)-(dimethylamino)methylene]amino]phenyl]-N'-(2-hydroxy-1,1-dimethylethyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 2131230-48-1
(E)-N'-(4-amino-2-cyanophenyl)-N,N-dimethylformimidamide

: 124-68-5
2-Amino-2-methyl-1-propanol

: 6160-65-2
1,1'-Thiocarbonyldiimidazole

: 1429755-57-6
N-[3-cyano-4-[[(1E)-(dimethylamino)methylene]amino]phenyl]-N'-(2-hydroxy-1,1-dimethylethyl)thiourea

Guidance literature:: In tetrahydrofuran; at -14 ℃;
DOI:10.1158/1535-7163.MCT-19-0873

Reference yield: 46.72%

: 2131230-48-1
(E)-N'-(4-amino-2-cyanophenyl)-N,N-dimethylformimidamide

: 88681-68-9
di(1H-imidazol-2-yl)methanethione

: 124-68-5
2-Amino-2-methyl-1-propanol

: 1429755-57-6
N-[3-cyano-4-[[(1E)-(dimethylamino)methylene]amino]phenyl]-N'-(2-hydroxy-1,1-dimethylethyl)thiourea

Guidance literature:: (E)-N'-(4-amino-2-cyanophenyl)-N,N-dimethylformimidamide; di(1H-imidazol-2-yl)methanethione; In tetrahydrofuran; at -5 - 0 ℃; for 0.5h;

2-Amino-2-methyl-1-propanol; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

: (E)-N'-(2-cyano-4-nitrophenyl)-N,N-dimethylimidoformamide

: 1429755-57-6
N-[3-cyano-4-[[(1E)-(dimethylamino)methylene]amino]phenyl]-N'-(2-hydroxy-1,1-dimethylethyl)thiourea

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol; cyclohexene / 18 h / 80 °C

2.1: tetrahydrofuran / 0.5 h / -5 - 0 °C

2.2: 18 h / 20 °C

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; cyclohexene;