3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylbenzoic acid

Base Information

Chemical Name:3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylbenzoic acid
CAS No.:1447666-97-8
Molecular Formula:C₃₄H₃₅FO₅
Molecular Weight:542.647
Hs Code.:

Synonyms:3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylbenzoic acid

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Chemical Property of 3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylbenzoic acid

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Technology Process of 3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylbenzoic acid

There total 7 articles about 3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1447666-96-7
methyl 3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylbenzoate

: 1447666-97-8
3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylbenzoic acid

Guidance literature:: methyl 3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylbenzoate; With potassium hydroxide; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 0.416667h;

With hydrogenchloride; In 1-methyl-pyrrolidin-2-one; water;

Reference yield:

: 1409654-45-0
tert-butyl 2,3-dimethoxybenzoate

: 1447666-97-8
3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylbenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / tetrahydrofuran; diethyl ether / 3.5 h / -12 - -10 °C

2.1: boron tribromide / toluene / 3 h / -25 - -5 °C

2.2: 0.5 h / 7 °C

3.1: thionyl chloride / 35.5 h / -10 °C

4.1: potassium carbonate; dmap / dimethyl sulfoxide / 87 h / 60 °C

5.1: potassium hydroxide / 1-methyl-pyrrolidin-2-one / 0.42 h / 120 °C

With dmap; thionyl chloride; boron tribromide; potassium carbonate; acetic acid; potassium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; dimethyl sulfoxide; toluene;

Reference yield:

: 1521-38-6
2,3-dimethoxybenzoic acid

: 1447666-97-8
3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylbenzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: N,N-dimethyl-formamide; thionyl chloride / toluene / 1 h / 40 °C

2.1: pyridine; dmap / dichloromethane / 1.08 h / Reflux

3.1: acetic acid / tetrahydrofuran; diethyl ether / 3.5 h / -12 - -10 °C

4.1: boron tribromide / toluene / 3 h / -25 - -5 °C

4.2: 0.5 h / 7 °C

5.1: thionyl chloride / 35.5 h / -10 °C

6.1: potassium carbonate; dmap / dimethyl sulfoxide / 87 h / 60 °C

7.1: potassium hydroxide / 1-methyl-pyrrolidin-2-one / 0.42 h / 120 °C

With pyridine; dmap; thionyl chloride; boron tribromide; potassium carbonate; acetic acid; N,N-dimethyl-formamide; potassium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; dichloromethane; dimethyl sulfoxide; toluene;