6-(dimethylamino)-N-(1H-tetrazol-5-yl)-2-pyrazinecarboxamide

Base Information

• Chemical Name: 6-(dimethylamino)-N-(1H-tetrazol-5-yl)-2-pyrazinecarboxamide
• CAS No.: 111374-19-7
• Molecular Formula: C₈H₁₀N₈O
• Molecular Weight: 234.22
• Mol file: 111374-19-7.mol

Synonyms:Pyrazinecarboxamide,6-(dimethylamino)-N-1H-tetrazol-5-yl- (9CI)

Chemical Property of 6-(dimethylamino)-N-(1H-tetrazol-5-yl)-2-pyrazinecarboxamide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 112.58000
• Density: 1.553g/cm³
• LogP: -0.61900

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(dimethylamino)-N-(1H-tetrazol-5-yl)-2-pyrazinecarboxamide

There total 3 articles about 6-(dimethylamino)-N-(1H-tetrazol-5-yl)-2-pyrazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

6-chloro-N-(1H-tetrazol-5-yl)-2-pyrazinecarboxamide (111374-47-1) + dimethyl amine (124-40-3) → 6-(dimethylamino)-N-(1H-5-tetrazolyl)pyrazine-2-carboxamide (111374-19-7)

Guidance literature:

In ethanol; at 80 - 90 ℃; for 24h;

DOI:10.1248/cpb.38.201

Reference yield:

5-aminotetrazole (4418-61-5) + pivaloyl chloride (3282-30-2) + 6-dimethylamino-pyrazine-2-carboxylic acid (40262-53-1) → 6-(dimethylamino)-N-(1H-5-tetrazolyl)pyrazine-2-carboxamide (111374-19-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; water;

Reference yield:

6-chloropyrazine-2-carboxylic acid (23688-89-3) → 6-(dimethylamino)-N-(1H-5-tetrazolyl)pyrazine-2-carboxamide (111374-19-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) pivaloyl chloride / 1) tetrahydrofuran, 5 deg C, 1 h, 2) a) room temperature, 1 h, b) reflux, 6 h

2: 74 percent / ethanol / 24 h / 80 - 90 °C

With pivaloyl chloride; In ethanol;

DOI:10.1248/cpb.38.201

upstream raw materials:

6-chloro-N-(1H-tetrazol-5-yl)-2-pyrazinecarboxamide

dimethyl amine

6-chloropyrazine-2-carboxylic acid

5-aminotetrazole

Refernces

• 1、 -. "Pyrazine-2-carboxamide derivatives useful in treating allergic disease". . . Retrieved 2008/06/13.