(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-(2-chloro-6-difluoromethoxy-3-fluorophenyl)-methanol

Base Information

Chemical Name:(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-(2-chloro-6-difluoromethoxy-3-fluorophenyl)-methanol
CAS No.:1350325-46-0
Molecular Formula:C₁₅H₉BrClF₃N₂O₂
Molecular Weight:421.601
Hs Code.:

Synonyms:(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-(2-chloro-6-difluoromethoxy-3-fluorophenyl)-methanol

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Chemical Property of (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-(2-chloro-6-difluoromethoxy-3-fluorophenyl)-methanol

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Technology Process of (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-(2-chloro-6-difluoromethoxy-3-fluorophenyl)-methanol

There total 1 articles about (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-(2-chloro-6-difluoromethoxy-3-fluorophenyl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350322-56-3
2-Chloro-6-difluoromethoxy-3-fluorobenzaldehyde

: 183208-35-7
5-bromo-1H-pyrrolo[2,3-b]pyridine

: 1350325-46-0
(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-(2-chloro-6-difluoromethoxy-3-fluorophenyl)-methanol

: 1413875-40-7
5-bromo-3-{[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-(methoxy)methyl}-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: 2-Chloro-6-difluoromethoxy-3-fluorobenzaldehyde; 5-bromo-1H-pyrrolo[2,3-b]pyridine; With potassium hydroxide; In methanol; at 20 ℃; for 48h;

With water; In methanol; for 0.5h; Cooling with ice;

Reference yield:

: 67-56-1
methanol

: 1350325-46-0
(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-(2-chloro-6-difluoromethoxy-3-fluorophenyl)-methanol

: 1413875-40-7
5-bromo-3-{[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-(methoxy)methyl}-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: methanol; (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-(2-chloro-6-difluoromethoxy-3-fluorophenyl)-methanol; hydrogenchloride; In diethyl ether; at 20 ℃; for 16h;

With sodium hydrogencarbonate; In water; for 0.5h; Cooling with ice;

Reference yield:

: 1350325-46-0
(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-(2-chloro-6-difluoromethoxy-3-fluorophenyl)-methanol

: 1413876-18-2
trans-4-[4-(3-{-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl]-2-fluoroethyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl]cyclohexanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / diethyl ether / 16 h / 20 °C

1.2: 0.5 h / Cooling with ice

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: 60 °C

2.3: 2 h / -78 - 20 °C

3.1: potassium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1.5 h / 90 °C / Inert atmosphere

4.1: disodium hydrogenphosphate; sodium amalgam; methanol / tetrahydrofuran / 9 h / -78 °C / Inert atmosphere

With methanol; potassium fluoride; disodium hydrogenphosphate; sodium amalgam; n-butyllithium; hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; water;