1-(2-(2-chloro-4-fluorobenzyloxy)-2-phenylethyl)-4-phenyl-1H-1,2,3-triazole

Base Information

Chemical Name:1-(2-(2-chloro-4-fluorobenzyloxy)-2-phenylethyl)-4-phenyl-1H-1,2,3-triazole
CAS No.:1415406-36-8
Molecular Formula:C₂₃H₁₉ClFN₃O
Molecular Weight:407.875
Hs Code.:

Synonyms:1-(2-(2-chloro-4-fluorobenzyloxy)-2-phenylethyl)-4-phenyl-1H-1,2,3-triazole

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Chemical Property of 1-(2-(2-chloro-4-fluorobenzyloxy)-2-phenylethyl)-4-phenyl-1H-1,2,3-triazole

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Technology Process of 1-(2-(2-chloro-4-fluorobenzyloxy)-2-phenylethyl)-4-phenyl-1H-1,2,3-triazole

There total 4 articles about 1-(2-(2-chloro-4-fluorobenzyloxy)-2-phenylethyl)-4-phenyl-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1210937-93-1
1-phenyl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethan-1-ol

: 45767-66-6
2-chloro-4-fluorobenzylbromide

: 1415406-36-8
1-(2-(2-chloro-4-fluorobenzyloxy)-2-phenylethyl)-4-phenyl-1H-1,2,3-triazole

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 2h;
DOI:10.1016/j.tetlet.2012.09.129

Reference yield:

: 98-86-2
acetophenone

: 1415406-36-8
1-(2-(2-chloro-4-fluorobenzyloxy)-2-phenylethyl)-4-phenyl-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide; toluene-4-sulfonic acid / acetonitrile / 4 h / Reflux

2: sodium azide; copper(l) iodide / water / 2 h / 25 - 30 °C

3: sodium tetrahydroborate / methanol / 16 h / 25 - 30 °C

4: sodium hydride / N,N-dimethyl-formamide / 2 h

With sodium tetrahydroborate; N-Bromosuccinimide; copper(l) iodide; sodium azide; sodium hydride; toluene-4-sulfonic acid; In methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tetlet.2012.09.129

Reference yield:

: 70-11-1
α-bromoacetophenone

: 1415406-36-8
1-(2-(2-chloro-4-fluorobenzyloxy)-2-phenylethyl)-4-phenyl-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide; copper(l) iodide / water / 2 h / 25 - 30 °C

2: sodium tetrahydroborate / methanol / 16 h / 25 - 30 °C

3: sodium hydride / N,N-dimethyl-formamide / 2 h

With sodium tetrahydroborate; copper(l) iodide; sodium azide; sodium hydride; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2012.09.129