(R)-4-chloro-N-(1-(6-((dimethylamino)methyl)-1-ethyl-1Hbenzo[d]imidazol-2-yl)ethyl)benzenesulfonamide

Base Information

Chemical Name:(R)-4-chloro-N-(1-(6-((dimethylamino)methyl)-1-ethyl-1Hbenzo[d]imidazol-2-yl)ethyl)benzenesulfonamide
CAS No.:1025507-02-1
Molecular Formula:C₂₀H₂₅ClN₄O₂S
Molecular Weight:420.963
Hs Code.:

Synonyms:(R)-4-chloro-N-(1-(6-((dimethylamino)methyl)-1-ethyl-1Hbenzo[d]imidazol-2-yl)ethyl)benzenesulfonamide

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Chemical Property of (R)-4-chloro-N-(1-(6-((dimethylamino)methyl)-1-ethyl-1Hbenzo[d]imidazol-2-yl)ethyl)benzenesulfonamide

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Technology Process of (R)-4-chloro-N-(1-(6-((dimethylamino)methyl)-1-ethyl-1Hbenzo[d]imidazol-2-yl)ethyl)benzenesulfonamide

There total 7 articles about (R)-4-chloro-N-(1-(6-((dimethylamino)methyl)-1-ethyl-1Hbenzo[d]imidazol-2-yl)ethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1025508-15-9
4-chloro-N-[(R)-1-(1-ethyl-6-formyl-1H-benzoimidazol-2-yl)ethyl]benzenesulfonamide

: 124-40-3
dimethyl amine

: 1025507-02-1
(R)-4-chloro-N-(1-(6-((dimethylamino)methyl)-1-ethyl-1Hbenzo[d]imidazol-2-yl)ethyl)benzenesulfonamide

Guidance literature:: With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 18 - 25 ℃;

Reference yield:

: C₁₄H₂₂N₄

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 1025507-02-1
(R)-4-chloro-N-(1-(6-((dimethylamino)methyl)-1-ethyl-1Hbenzo[d]imidazol-2-yl)ethyl)benzenesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1021/acs.jmedchem.5b01078

Reference yield:

: C₉H₁₁ClN₂O₂

: 1025507-02-1
(R)-4-chloro-N-(1-(6-((dimethylamino)methyl)-1-ethyl-1Hbenzo[d]imidazol-2-yl)ethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: 2 h / Microwave irradiation; Sealed tube

2: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr / Inert atmosphere

3: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C

4: acetic acid / 2 h / 65 °C

5: hydrogenchloride / water; 1,4-dioxane / 2 h / 20 °C

6: triethylamine / dichloromethane / 2 h / 0 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; acetic acid; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b01078