4-{(S)-4-carboxy-2-[(4-chloro-6-phenyl-pyridine-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4-{(S)-4-carboxy-2-[(4-chloro-6-phenyl-pyridine-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester
• CAS No.: 1019923-81-9
• Molecular Formula: C₂₄H₂₇ClN₄O₆
• Molecular Weight: 502.955

Synonyms:4-{(S)-4-carboxy-2-[(4-chloro-6-phenyl-pyridine-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester

Chemical Property of 4-{(S)-4-carboxy-2-[(4-chloro-6-phenyl-pyridine-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 4-{(S)-4-carboxy-2-[(4-chloro-6-phenyl-pyridine-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester

There total 1 articles about 4-{(S)-4-carboxy-2-[(4-chloro-6-phenyl-pyridine-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-[(2S)-5-tert-butoxy-2-([(4-chloro-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl]piperazine-1-carboxylate (1019925-07-5) → 4-{(S)-4-carboxy-2-[(4-chloro-6-phenyl-pyridine-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester (1019923-81-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

4-aminotetrahydropyran (38041-19-9) + 4-{(S)-4-carboxy-2-[(4-chloro-6-phenyl-pyridine-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester (1019923-81-9) → C29H37N5O7 (1188276-16-5)

Guidance literature:

With triethylamine; In dimethyl sulfoxide; at 100 ℃;

DOI:10.1016/j.bmcl.2009.06.075

Reference yield:

4-aminopiperidine (13035-19-3) + 4-{(S)-4-carboxy-2-[(4-chloro-6-phenyl-pyridine-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester (1019923-81-9) → (4S)-4-(([4-(4-aminopiperidin-1-yl)-6-phenylpyridin-2-yl]carbonyl)amino)-5-[4-(ethoxycarbonyl)piperazin-1-yl]-5-oxopentanoic acid (1188276-22-3)

Guidance literature:

With triethylamine; In dimethyl sulfoxide; at 100 ℃;

DOI:10.1016/j.bmcl.2009.06.075

upstream raw materials:

ethyl 4-[(2S)-5-tert-butoxy-2-([(4-chloro-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl]piperazine-1-carboxylate

Downstream raw materials:

C₂₉H₃₇N₅O₇

C₃₂H₄₅N₇O₆

(4S)-5-[4-(ethoxycarbonyl)piperazin-1-yl]-5-oxo-4-({[6-phenyl-4-(propylamino)pyridin-2-yl]carbonyl}amino)pentanoic acid

(4S)-4-(([4-(4-aminopiperidin-1-yl)-6-phenylpyridin-2-yl]carbonyl)amino)-5-[4-(ethoxycarbonyl)piperazin-1-yl]-5-oxopentanoic acid

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