α-diazo-1-{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}ethanone

Base Information

Chemical Name:α-diazo-1-{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}ethanone
CAS No.:1268385-56-3
Molecular Formula:C₁₆H₁₃F₃N₄O₂
Molecular Weight:350.3
Hs Code.:

Synonyms:α-diazo-1-{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}ethanone

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Chemical Property of α-diazo-1-{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}ethanone

Chemical Property:

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Technology Process of α-diazo-1-{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}ethanone

There total 4 articles about α-diazo-1-{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 1268385-61-0
C₁₅H₁₂ClF₃N₂O₂

: 1268385-56-3
α-diazo-1-{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}ethanone

Guidance literature:: In diethyl ether; at 20 ℃;

Reference yield:

: 287714-35-6
2-chloro-pyrimidine-5-carboxylic acid methyl ester

: 1268385-56-3
α-diazo-1-{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 120 °C / Inert atmosphere; Microwave

2: water; lithium hydroxide / tetrahydrofuran / 1 h / 20 °C

3: thionyl chloride / 2 h / Reflux

4: diethyl ether / 20 °C

With potassium phosphate; thionyl chloride; water; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water;

Reference yield:

: 1186482-51-8
(4-propoxy-2-(trifluoromethyl)phenyl)boronic acid

: 1268385-56-3
α-diazo-1-{2-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-pyrimidinyl}ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 120 °C / Inert atmosphere; Microwave

2: water; lithium hydroxide / tetrahydrofuran / 1 h / 20 °C

3: thionyl chloride / 2 h / Reflux

4: diethyl ether / 20 °C

With potassium phosphate; thionyl chloride; water; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water;