90369-76-9

Basic information

• Product Name: 1-(bromomethyl)-3-chloro-2-methylbenzene
• Synonyms: 1-(bromomethyl)-3-chloro-2-methylbenzene;Benzene, 1-(bromomethyl)-3-chloro-2-methyl-;3-CHLORO-2-METHYLBENZYL BROMIDE
• CAS NO: 90369-76-9
• Molecular Formula: C₈H₈BrCl
• Molecular Weight: 219.50612
• Mol File: 90369-76-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1-(bromomethyl)-3-chloro-2-methylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(bromomethyl)-3-chloro-2-methylbenzene(90369-76-9)
• EPA Substance Registry System: 1-(bromomethyl)-3-chloro-2-methylbenzene(90369-76-9)

Safety Data

• Hazardous Substances Data: 90369-76-9(Hazardous Substances Data)

Usage

General Description

1-(bromomethyl)-3-chloro-2-methylbenzene is a chemical compound with the molecular formula C8H8BrCl. It is a derivative of benzene, with a bromomethyl group, a chloro group, and a methyl group attached to the benzene ring. 1-(bromomethyl)-3-chloro-2-methylbenzene is a colorless to pale yellow liquid with a boiling point of 230-231°C. It is primarily used as an intermediate in the production of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a reagent in organic synthesis reactions. 1-(bromomethyl)-3-chloro-2-methylbenzene is a hazardous chemical and should be handled with proper safety precautions.

Upstream product

• 7499-08-3 3-chloro-2-methylbenzoic acid 
• 54454-12-5 (3-chloro-2-methylphenyl)carbonitrile 
• 874-27-1 3-Chloro-2-methylbenzaldehyde 
• 118-69-4 2,6-dichlorotoluene 
• 90369-75-8 (3-chloro-2-methyl-phenyl)methanol 

Downstream Products

• 1372540-46-9 methyl 1-[(3-chloro-2-methylphenyl)methyl]-6-(4-morpholinyl)-2-(trifluoromethyl)-1H-benzimidazole-4-carboxylate 
• 1445877-24-6 methyl 3-(3-chloro-2-methylbenzyl)-2-methyl-5-morpholino-3H-imidazo[4,5-b]pyridine-7-carboxylate 
• 1443541-30-7 4-bromo-1-(3-chloro-2-methylbenzyl)-2-(fluoromethyl)-6-nitro-1H-benzo[d]imidazole 
• 1443541-23-8 4-bromo-1-(3-chloro-2-methylbenzyl)-6-nitro-1H-benzo[d]imidazole 
• 35703-53-8 2-(3-chloro-2-methylphenyl)acetonitrile 
• 90369-81-6 3,3'-bis(bromomethyl)-2,2'-dimethylbenzophenone 
• 90369-88-3 Bis(3-(mercaptomethyl)-2-methylphenyl) Ketone 
• 90369-93-0 C₁₉H₂₄N₄OS₂⁽²⁺⁾*2Br^(1-) 
• 90369-79-2 Bis(3-(methoxymethyl)-2-methylphenyl)methanol 
• 90369-82-7 Bis(3-(methoxymethyl)-2-methylphenyl)methane 
• 90369-80-5 Bis(3-(methoxymethyl)-2-methylphenyl) Ketone 
• 90369-83-8 Bis(3-(bromomethyl)-2-methylphenyl)methane 
• 90369-84-9 Bis(3-(mercaptomethyl)-2-methylphenyl)methane 
• 90369-78-1 3-(Methoxymethyl)-2-methylbenzonitrile 

Relevant articles and documents

Enantioselective Intermolecular C-H Amination Directed by a Chiral Cation

The enantioselective amination of C(sp3)-H bonds is a powerful synthetic transformation yet highly challenging to achieve in an intermolecular sense. We have developed a family of anionic variants of the best-in-class catalyst for Rh-catalyzed C-H amination, Rh2(esp)2, with which we have associated chiral cations derived from quaternized cinchona alkaloids. These ion-paired catalysts enable high levels of enantioselectivity to be achieved in the benzylic C-H amination of substrates bearing pendant hydroxyl groups. Additionally, the quinoline of the chiral cation appears to engage in axial ligation to the rhodium complex, providing improved yields of product versus Rh2(esp)2 and highlighting the dual role that the cation is playing. These results underline the potential of using chiral cations to control enantioselectivity in challenging transition-metal-catalyzed transformations.

THIAZOLOPYRIMIDINONE DERIVATIVES AS PI3 KINASE INHIBITORS

This invention relates to the use of thiazolopyrimidinone derivatives for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3' OH kinase family (hereinafter PI3 kinases), suitably, PI3Kα, PI3Kδ, PI3Kβ, and/or PI3Kγ

Synthesis, reactions, and structural and NMR features of [2.2]metacyclophane monoenes and their tricarbonylchromium and cyclopentadienyliron(+) complexes

8,16-Dimethyl-, 5,8,13,16-tetramethyl-, and 4,6,8,12,14,16- hexamethyl[2.2]metacyclophanene have been synthesized from the corresponding methyl-substituted 3-thia[3.2]metacyclophane precursors via a Wittig rearrangement-Hofmann elimination procedure. Simp