N-tert-butoxycarbonyl-O-tert-butyldimethylsilyl-(R)-β-tyrosine tert-butyl ester

Base Information

• Chemical Name: N-tert-butoxycarbonyl-O-tert-butyldimethylsilyl-(R)-β-tyrosine tert-butyl ester
• CAS No.: 112896-92-1
• Molecular Formula: C₂₄H₄₁NO₅Si
• Molecular Weight: 451.679

Synonyms:N-tert-butoxycarbonyl-O-tert-butyldimethylsilyl-(R)-β-tyrosine tert-butyl ester

Chemical Property of N-tert-butoxycarbonyl-O-tert-butyldimethylsilyl-(R)-β-tyrosine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tert-butoxycarbonyl-O-tert-butyldimethylsilyl-(R)-β-tyrosine tert-butyl ester

There total 5 articles about N-tert-butoxycarbonyl-O-tert-butyldimethylsilyl-(R)-β-tyrosine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

(S)-N-tert-butoxycarbonyl-4-tert-butyldimethylsilyloxy-α-diazoacetylbenzylamine (112896-91-0) + tert-butyl alcohol (75-65-0) → N-tert-butoxycarbonyl-O-tert-butyldimethylsilyl-(R)-β-tyrosine tert-butyl ester (112896-92-1)

Guidance literature:

With silver benzoate; triethylamine;

DOI:10.1021/ja00213a050

Reference yield:

N-tert-butyloxycarbonyl-L-4-hydroxyphenylglycine (69651-48-5) → N-tert-butoxycarbonyl-O-tert-butyldimethylsilyl-(R)-β-tyrosine tert-butyl ester (112896-92-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / imidazole / dimethylformamide / 9 h / Ambient temperature

2: 1.) ClCO₂Et, Et₃N / 1.) ether, 0 deg C, 1 h, 2.) ether, RT, 7 h

3: 50 percent / silver benzoate, Et₃N / 0.05 h / 80 °C

With 1H-imidazole; silver benzoate; chloroformic acid ethyl ester; triethylamine; In N,N-dimethyl-formamide;

DOI:10.3987/COM-94-S(B)52

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → N-tert-butoxycarbonyl-O-tert-butyldimethylsilyl-(R)-β-tyrosine tert-butyl ester (112896-92-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / imidazole / dimethylformamide / 9 h / Ambient temperature

2: 1.) ClCO₂Et, Et₃N / 1.) ether, 0 deg C, 1 h, 2.) ether, RT, 7 h

3: 50 percent / silver benzoate, Et₃N / 0.05 h / 80 °C

With 1H-imidazole; silver benzoate; chloroformic acid ethyl ester; triethylamine; In N,N-dimethyl-formamide;

DOI:10.3987/COM-94-S(B)52

upstream raw materials:

(S)-N-tert-butoxycarbonyl-4-tert-butyldimethylsilyloxy-α-diazoacetylbenzylamine

tert-butyl alcohol

N-tert-butyloxycarbonyl-L-4-hydroxyphenylglycine

(S)-hydroxyphenylglycine

Downstream raw materials:

O-tert-butyldimethylsilyl-(R)-β-tyrosine tert-but

(R)-3-((R)-3-(2-Bromo-1H-indol-3-yl)-2-{[(S)-2-((E)-(2S,6R,8S)-8-methoxymethoxy-2,4,6-trimethyl-non-4-enoylamino)-propionyl]-methyl-amino}-propionylamino)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid tert-butyl ester

(2S,4E,6R,8S)-8-tert-butyldimethylsilyloxy-2,4,6-trimethyl-4-nonenoyl-(S)-alanyl-N-methyl-2-bromo-(R)-tryptophanyl-O-tert-butyldimethylsilyl-(R)-β-tyrosine tert-butyl ester

(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-(S)-alanyl-N-methyl-2-bromo-(R)-tryptophanyl-O-tert-butyldimethylsilyl-(R)-β-tyrosine ρ-lactone

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 112896-92-1 N-tert-butoxycarbonyl-O-tert-butyldimethylsilyl-(R)-β-tyrosine tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send