N'-[3-[(2E)-3-(dimethylamino)-2-propenoyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-N,N-dimethylimidoformamide

Base Information

Chemical Name:N'-[3-[(2E)-3-(dimethylamino)-2-propenoyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-N,N-dimethylimidoformamide
CAS No.:481049-29-0
Molecular Formula:C₂₁H₂₂FN₅O
Molecular Weight:379.437
Hs Code.:

Synonyms:N'-[3-[(2E)-3-(dimethylamino)-2-propenoyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-N,N-dimethylimidoformamide

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Chemical Property of N'-[3-[(2E)-3-(dimethylamino)-2-propenoyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-N,N-dimethylimidoformamide

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Technology Process of N'-[3-[(2E)-3-(dimethylamino)-2-propenoyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-N,N-dimethylimidoformamide

There total 5 articles about N'-[3-[(2E)-3-(dimethylamino)-2-propenoyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-N,N-dimethylimidoformamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 481049-28-9
1-[8-amino-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]ethanone

: 481049-29-0
N'-[3-[(2E)-3-(dimethylamino)-2-propenoyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-N,N-dimethylimidoformamide

Guidance literature:: for 144h; Heating;
DOI:10.1021/ol0343616

Reference yield:

: 4214-75-9
2-amino-3-nitropyridine

: 481049-29-0
N'-[3-[(2E)-3-(dimethylamino)-2-propenoyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-N,N-dimethylimidoformamide

Guidance literature:: Multi-step reaction with 4 steps

1: 36 percent / dimethylformamide / 6 h / Heating

2: 55 percent / aq. H₂SO₄ / 1 h / Heating

3: 80 percent / Fe; aq. NH₄Cl / methanol / 10 h / Heating

4: 62 percent / 144 h / Heating

With sulfuric acid; iron; ammonium chloride; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/ol0343616

Reference yield:

: 403-29-2
2-bromo-4'-fluoroacetophenone

: 481049-29-0
N'-[3-[(2E)-3-(dimethylamino)-2-propenoyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-N,N-dimethylimidoformamide

Guidance literature:: Multi-step reaction with 4 steps

1: 36 percent / dimethylformamide / 6 h / Heating

2: 55 percent / aq. H₂SO₄ / 1 h / Heating

3: 80 percent / Fe; aq. NH₄Cl / methanol / 10 h / Heating

4: 62 percent / 144 h / Heating

With sulfuric acid; iron; ammonium chloride; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/ol0343616