2-[4-(4-amino-phenylethynyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-3-yl]-4-chloro-phenol

Base Information

Chemical Name:2-[4-(4-amino-phenylethynyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-3-yl]-4-chloro-phenol
CAS No.:1020839-87-5
Molecular Formula:C₁₉H₁₆ClN₃O₂
Molecular Weight:353.808
Hs Code.:

Synonyms:2-[4-(4-amino-phenylethynyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-3-yl]-4-chloro-phenol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[4-(4-amino-phenylethynyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-3-yl]-4-chloro-phenol

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Technology Process of 2-[4-(4-amino-phenylethynyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-3-yl]-4-chloro-phenol

There total 1 articles about 2-[4-(4-amino-phenylethynyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-3-yl]-4-chloro-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.5%

: 73220-39-0
6-chloro-3-iodo-4H-chromen-4-one

: 109-84-2
2-hydroxyethylhydrazine

: 14235-81-5
4-Ethynylaniline

: 1020839-87-5
2-[4-(4-amino-phenylethynyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-3-yl]-4-chloro-phenol

Guidance literature:: 6-chloro-3-iodo-4H-chromen-4-one; 4-Ethynylaniline; With copper(l) iodide; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In acetonitrile; at 20 ℃; for 5h;

2-hydroxyethylhydrazine; In acetonitrile; for 20h;

Reference yield: 72.6%

: 1020839-87-5
2-[4-(4-amino-phenylethynyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-3-yl]-4-chloro-phenol

: 28697-17-8
N-BOC-D-pipecolic acid

: 1020839-90-0
2(R)-{4-[3-(5-chloro-2-hydroxy-phenyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-4-ylethynyl]-phenylcarbamoyl}-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: 2-[4-(4-amino-phenylethynyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-3-yl]-4-chloro-phenol; N-BOC-D-pipecolic acid; With dmap; diisopropyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃;

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 0 ℃; for 2h;

Reference yield: 71.7%

: 212650-43-6
4-(tert-butoxycarbonyl)morpholine-3-carboxylic acid

: 1020839-87-5
2-[4-(4-amino-phenylethynyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-3-yl]-4-chloro-phenol

: 1020840-10-1
3(R,S)-{4-[3-(5-chloro-2-hydroxy-phenyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-4-ylethynyl]-phenylcarbamoyl}-morpholine-4-carboxylic acid tert-butyl ester

Guidance literature:: 4-(tert-butoxycarbonyl)morpholine-3-carboxylic acid; 2-[4-(4-amino-phenylethynyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-3-yl]-4-chloro-phenol; With diisopropyl-carbodiimide; In tetrahydrofuran; at 20 ℃;

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 4h;