methanesulfonic acid (1R,2R)-2-<(tert-butoxycarbonyl)amino>-1-<<(tert-butyldimethylsilyl)oxy>methyl>-2-phenylethyl ester

Base Information

Chemical Name:methanesulfonic acid (1R,2R)-2-<(tert-butoxycarbonyl)amino>-1-<<(tert-butyldimethylsilyl)oxy>methyl>-2-phenylethyl ester
CAS No.:218797-62-7
Molecular Formula:C₂₁H₃₇NO₆SSi
Molecular Weight:459.679
Hs Code.:

Synonyms:methanesulfonic acid (1R,2R)-2-<(tert-butoxycarbonyl)amino>-1-<<(tert-butyldimethylsilyl)oxy>methyl>-2-phenylethyl ester

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Chemical Property of methanesulfonic acid (1R,2R)-2-<(tert-butoxycarbonyl)amino>-1-<<(tert-butyldimethylsilyl)oxy>methyl>-2-phenylethyl ester

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Technology Process of methanesulfonic acid (1R,2R)-2-<(tert-butoxycarbonyl)amino>-1-<<(tert-butyldimethylsilyl)oxy>methyl>-2-phenylethyl ester

There total 3 articles about methanesulfonic acid (1R,2R)-2-<(tert-butoxycarbonyl)amino>-1-<<(tert-butyldimethylsilyl)oxy>methyl>-2-phenylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 124-63-0
methanesulfonyl chloride

: 153704-74-6
(2R,3R)-1-<(tert-butyldimethylsilyl)oxy>-3-<(tert-butoxycarbonyl)amino>-3-phenyl-2-propanol

: 218797-62-7
methanesulfonic acid (1R,2R)-2-<(tert-butoxycarbonyl)amino>-1-<<(tert-butyldimethylsilyl)oxy>methyl>-2-phenylethyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at -15 - 23 ℃; for 5h;
DOI:10.1021/jo981140i

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 218797-62-7
methanesulfonic acid (1R,2R)-2-<(tert-butoxycarbonyl)amino>-1-<<(tert-butyldimethylsilyl)oxy>methyl>-2-phenylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

2: 83 percent / triethylamine, 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 5 h / -15 - 23 °C

With 1H-imidazole; dmap; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo981140i

Reference yield:

: 125414-45-1
(2R,3R)-3-<(tert-butoxycarbonyl)amino>-3-phenyl-1,2-propanediol

: 218797-62-7
methanesulfonic acid (1R,2R)-2-<(tert-butoxycarbonyl)amino>-1-<<(tert-butyldimethylsilyl)oxy>methyl>-2-phenylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

2: 83 percent / triethylamine, 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 5 h / -15 - 23 °C

With 1H-imidazole; dmap; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo981140i