4-fluoro-N-((5-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)carbamothioyl)benzamide

Base Information

Chemical Name:4-fluoro-N-((5-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)carbamothioyl)benzamide
CAS No.:1567837-79-9
Molecular Formula:C₂₆H₁₉FN₄O₂S₂
Molecular Weight:502.593
Hs Code.:

Synonyms:4-fluoro-N-((5-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)carbamothioyl)benzamide

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Chemical Property of 4-fluoro-N-((5-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)carbamothioyl)benzamide

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Technology Process of 4-fluoro-N-((5-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)carbamothioyl)benzamide

There total 8 articles about 4-fluoro-N-((5-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)carbamothioyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 1567836-37-6
5-(5-(5-aminopyridin-3-yl)thiophen-2-yl)-2-methylisoindolin-1-one

: 333-20-0
potassium thioacyanate

: 403-43-0
4-fluorobenzoyl chloride

: 1567837-79-9
4-fluoro-N-((5-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)carbamothioyl)benzamide

Guidance literature:: potassium thioacyanate; 4-fluorobenzoyl chloride; In acetone; at 50 ℃; for 1h;

5-(5-(5-aminopyridin-3-yl)thiophen-2-yl)-2-methylisoindolin-1-one; In acetone; at 50 ℃; for 4h;

Reference yield:

: 1567836-35-4
2-methyl-5-(thiophen-2-yl)isoindolin-1-one

: 1567837-79-9
4-fluoro-N-((5-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)carbamothioyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; N-iodo-succinimide / chloroform / 20 °C

2.1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; toluene / Reflux; Inert atmosphere

3.1: acetone / 1 h / 50 °C

3.2: 4 h / 50 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; sodium carbonate; acetic acid; In ethanol; chloroform; acetone; toluene;

Reference yield:

: 1567836-36-5
5-(5-iodothiophen-2-yl)-2-methylisoindolin-1-one

: 1567837-79-9
4-fluoro-N-((5-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)carbamothioyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; toluene / Reflux; Inert atmosphere

2.1: acetone / 1 h / 50 °C

2.2: 4 h / 50 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In ethanol; acetone; toluene;