5-bromo-2-methylisoindolin-1-one

Base Information

• Chemical Name: 5-bromo-2-methylisoindolin-1-one
• CAS No.: 868066-91-5
• Molecular Formula: C9H8BrNO
• Molecular Weight: 226.073
• Hs Code.: 2933790090
• Mol file: 868066-91-5.mol

Synonyms:5-Bromo-2-methyl-2,3-dihydroisoindol-1-one;1H-isoindol-1-one, 5-bromo-2,3-dihydro-2-methyl-;

Chemical Property of 5-bromo-2-methylisoindolin-1-one

Chemical Property:

• Vapor Pressure: 2.98E-05mmHg at 25°C
• Refractive Index: 1.619
• Boiling Point: 356.2 °C at 760 mmHg
• PKA: -1.60±0.20(Predicted)
• Flash Point: 169.2 °C
• PSA: 20.31000
• Density: 1.589 g/cm³
• LogP: 1.97260
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

5-Bromo-2-methylisoindolin-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-bromo-2-methylisoindolin-1-one

There total 11 articles about 5-bromo-2-methylisoindolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-bromoisoindolin-1-one (552330-86-6) + methyl iodide (74-88-4) → 5-bromo-2-methyl-1,3-dihydroisoindol-1-one (868066-91-5)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; for 3h; Heating;

DOI:10.1021/acs.jmedchem.1c01792

Reference yield: 90.0%

→ 5-bromo-2-methyl-1,3-dihydroisoindol-1-one (868066-91-5)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 3h;

Reference yield: 83.0%

4-bromo-2-(hydroxymethyl)-N-methylbenzamide (888030-79-3) → (5-bromo-3H-isobenzofuran-1-ylidene)-methyl-amine + 5-bromo-2-methyl-1,3-dihydroisoindol-1-one (868066-91-5)

Guidance literature:

4-bromo-2-(hydroxymethyl)-N-methylbenzamide; With isopropylmagnesium chloride; In tetrahydrofuran; at 20 ℃;

With N,N,N',N'-Tetramethylphosphorodiamidic chloride; In tetrahydrofuran; at 20 ℃;

DOI:10.1055/s-2006-933114

upstream raw materials:

4-bromo-2-(hydroxymethyl)-N-methylbenzamide

(5-bromo-3H-isobenzofuran-1-ylidene)-isopropyl-amine

5-bromophthalide

dimethyl amine

Downstream raw materials:

2,4-difluoro-N-(5-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)benzenesulfonamide

4-fluoro-N-((5-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)carbamothioyl)benzamide

5-(5-(3-aminophenyl)thiophen-2-yl)-2-methylisoindolin-1-one

2,4-difluoro-N-(5-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)benzamide

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