(2S,3S)-2[(2S)-(4-tert-butoxybenzyl)-9-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepin-4-yl]-3-methylpentanoic acid

Base Information

• Chemical Name: (2S,3S)-2[(2S)-(4-tert-butoxybenzyl)-9-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepin-4-yl]-3-methylpentanoic acid
• CAS No.: 857041-11-3
• Molecular Formula: C₄₁H₄₅N₃O₆
• Molecular Weight: 675.825

Synonyms:(2S,3S)-2[(2S)-(4-tert-butoxybenzyl)-9-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepin-4-yl]-3-methylpentanoic acid

Chemical Property of (2S,3S)-2[(2S)-(4-tert-butoxybenzyl)-9-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepin-4-yl]-3-methylpentanoic acid

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Technology Process of (2S,3S)-2[(2S)-(4-tert-butoxybenzyl)-9-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepin-4-yl]-3-methylpentanoic acid

There total 1 articles about (2S,3S)-2[(2S)-(4-tert-butoxybenzyl)-9-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepin-4-yl]-3-methylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[9-amino-2-(4-tert-butoxy-benzyl)-3-oxo-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-3-methyl-pentanoic acid + (fluorenylmethoxy)carbonyl chloride (28920-43-6) → (2S,3S)-2[(2S)-(4-tert-butoxybenzyl)-9-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepin-4-yl]-3-methylpentanoic acid (857041-11-3)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; at 0 ℃; for 48h; pH=8 - 9;

DOI:10.1021/jm0491492

Reference yield:

(2S,3S)-2[(2S)-(4-tert-butoxybenzyl)-9-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepin-4-yl]-3-methylpentanoic acid (857041-11-3) + Fmoc-Val-OH (68858-20-8) + Fmoc-(tBu)Asp-OH (71989-14-5) + Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine (187618-60-6) → C57H76N14O12

Guidance literature:

Multistep reaction;

DOI:10.1021/jm0491492

Reference yield:

(2S,3S)-2[(2S)-(4-tert-butoxybenzyl)-9-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepin-4-yl]-3-methylpentanoic acid (857041-11-3) + N-Fmoc L-Phe (35661-40-6) + Fmoc-(tBu)Asp-OH (71989-14-5) + Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine (187618-60-6) → C52H67N13O11

Guidance literature:

Multistep reaction;

DOI:10.1021/jm0491492

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

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