2-amino-4-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)benzonitrile

Base Information

Chemical Name:2-amino-4-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)benzonitrile
CAS No.:1027345-32-9
Molecular Formula:C₂₄H₂₃ClN₄
Molecular Weight:402.926
Hs Code.:

Synonyms:2-amino-4-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)benzonitrile

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Chemical Property of 2-amino-4-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)benzonitrile

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Technology Process of 2-amino-4-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)benzonitrile

There total 7 articles about 2-amino-4-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1027345-30-7
C₂₄H₂₁ClN₄O₂

: 1027345-32-9
2-amino-4-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)benzonitrile

Guidance literature:: With iron; acetic acid; at 90 ℃; for 0.166667h;

Reference yield:

: 1027345-29-4
4-(4-(2-bromobenzyl)piperazin-1-yl)-2-nitrobenzonitrile

: 1027345-32-9
2-amino-4-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 4 h / 90 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: iron; acetic acid / 0.17 h / 90 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; iron; sodium carbonate; acetic acid; In 1,2-dimethoxyethane; ethanol; water; 1.1: Suzuki coupling;
DOI:10.1021/jm101596e

Reference yield:

: 4110-33-2
2,4-dinitrobenzonitrile

: 1027345-32-9
2-amino-4-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: dimethyl sulfoxide / 72 h / 25 °C / Inert atmosphere

2.1: acetonitrile / 2 h / Inert atmosphere

3.1: triethylamine / isopropyl alcohol / 3 h / Inert atmosphere

4.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 4 h / 90 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: iron; acetic acid / 0.17 h / 90 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; iron; sodium carbonate; acetic acid; triethylamine; In 1,2-dimethoxyethane; ethanol; water; dimethyl sulfoxide; isopropyl alcohol; acetonitrile; 4.1: Suzuki coupling;
DOI:10.1021/jm101596e