(2-chloro-4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy)phenyl)methanol

Base Information

Chemical Name:(2-chloro-4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy)phenyl)methanol
CAS No.:700835-89-8
Molecular Formula:C₂₀H₁₈Cl₃NO₃
Molecular Weight:426.727
Hs Code.:

Synonyms:(2-chloro-4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy)phenyl)methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2-chloro-4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy)phenyl)methanol

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Technology Process of (2-chloro-4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy)phenyl)methanol

There total 9 articles about (2-chloro-4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy)phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 278597-32-3
3-(2,6-dichlorophenyl)-4-(3'-chloro-4'-formylphenoxy)-methyl-5-isopropyl-isoxazole

: 700835-89-8
(2-chloro-4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy)phenyl)methanol

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃; for 1h;

Reference yield: 98.0%

: ethyl 2-chloro-4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy)benzoate

: 700835-89-8
(2-chloro-4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy)phenyl)methanol

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.0c00618

Reference yield:

: 83-38-5
2,6-dichlorobenzaldehyde

: 700835-89-8
(2-chloro-4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy)phenyl)methanol

Guidance literature:: Multi-step reaction with 6 steps

1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 12 h / 90 °C / Inert atmosphere

2: N-chloro-succinimide / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

3: sodium methylate / tetrahydrofuran; methanol / 12 h / 20 °C / Inert atmosphere

4: diisobutylaluminium hydride / tetrahydrofuran; toluene / 24 h / 0 - 20 °C / Inert atmosphere

5: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 4 h / 20 °C / Inert atmosphere

6: diisobutylaluminium hydride / tetrahydrofuran; toluene / 24 h / 0 - 20 °C / Inert atmosphere

With N-chloro-succinimide; di-isopropyl azodicarboxylate; hydroxylamine hydrochloride; sodium methylate; diisobutylaluminium hydride; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 5: |Mitsunobu Displacement;
DOI:10.1021/acs.jmedchem.0c00618