4,4-dimethyl-2-[4-(1-methylethyl)-2,3,5-trimethoxyphenyl-methyl]-1,3-cyclohexanedione

Base Information

• Chemical Name: 4,4-dimethyl-2-[4-(1-methylethyl)-2,3,5-trimethoxyphenyl-methyl]-1,3-cyclohexanedione
• CAS No.: 156723-08-9
• Molecular Formula: C₂₁H₃₀O₅
• Molecular Weight: 362.466
• Mol file: 156723-08-9.mol

Synonyms:4,4-dimethyl-2-[4-(1-methylethyl)-2,3,5-trimethoxyphenyl-methyl]-1,3-cyclohexanedione

Chemical Property of 4,4-dimethyl-2-[4-(1-methylethyl)-2,3,5-trimethoxyphenyl-methyl]-1,3-cyclohexanedione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4-dimethyl-2-[4-(1-methylethyl)-2,3,5-trimethoxyphenyl-methyl]-1,3-cyclohexanedione

There total 9 articles about 4,4-dimethyl-2-[4-(1-methylethyl)-2,3,5-trimethoxyphenyl-methyl]-1,3-cyclohexanedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4,4-dimethylcyclohexane-1,3-dione (562-46-9) + 2-(1-methylethyl)-1,3,4-trimethoxy-5-(bromomethyl)benzene (156723-07-8) → 4,4-dimethyl-2-[4-(1-methylethyl)-2,3,5-trimethoxyphenyl-methyl]-1,3-cyclohexanedione (156723-08-9)

Guidance literature:

With potassium carbonate; potassium iodide;

DOI:10.1021/ja00090a050

Reference yield:

1-bromo-2,3,5-trimethoxybenzene (23030-39-9) → 4,4-dimethyl-2-[4-(1-methylethyl)-2,3,5-trimethoxyphenyl-methyl]-1,3-cyclohexanedione (156723-08-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) n-BuLi

2: 1.) H₂SO₄, 2.) BF₃

3: 98 percent / LiAlH₄

4: 77 percent / PBr₃

5: 89 percent / 20percent aq. K₂CO₃, KI

With lithium aluminium tetrahydride; n-butyllithium; sulfuric acid; boron trifluoride; phosphorus tribromide; potassium carbonate; potassium iodide;

DOI:10.1021/ja00090a050

Reference yield:

2,3,5-trimethoxybenzoic acid (36873-96-8) → 4,4-dimethyl-2-[4-(1-methylethyl)-2,3,5-trimethoxyphenyl-methyl]-1,3-cyclohexanedione (156723-08-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) H₂SO₄, 2.) BF₃

2: 98 percent / LiAlH₄

3: 77 percent / PBr₃

4: 89 percent / 20percent aq. K₂CO₃, KI

With lithium aluminium tetrahydride; sulfuric acid; boron trifluoride; phosphorus tribromide; potassium carbonate; potassium iodide;

DOI:10.1021/ja00090a050

upstream raw materials:

4,4-dimethylcyclohexane-1,3-dione

2-(1-methylethyl)-1,3,4-trimethoxy-5-(bromomethyl)benzene

1-bromo-2,3,5-trimethoxybenzene

2,3,5-trimethoxybenzoic acid

Downstream raw materials:

3-methoxy-6,6-dimethyl-2-[4-(1-methylethyl)-2,3,5-trimethoxyphenylmethyl]-2-cyclohexenone

C₃₃H₄₁F₃O₆

C₃₃H₄₁F₃O₆