2-(2-Pyridylamino)ethyldimethylamine

Base Information

• Chemical Name: 2-(2-Pyridylamino)ethyldimethylamine
• CAS No.: 23826-72-4
• Molecular Formula: C9H15 N3
• Molecular Weight: 165.238
• Hs Code.: 2933399090
• European Community (EC) Number: 245-898-7
• NSC Number: 30154
• UNII: 024Q9A52OA
• DSSTox Substance ID: DTXSID20178533
• Nikkaji Number: J51.317B
• Wikidata: Q63398551
• ChEMBL ID: CHEMBL1489836
• Mol file: 23826-72-4.mol

Synonyms:23826-72-4;2-(2-Pyridylamino)ethyldimethylamine;N',N'-dimethyl-N-pyridin-2-ylethane-1,2-diamine;Pyridine, 2-(2-(dimethylamino)ethylamino)-;R.518;NSC30154;EINECS 245-898-7;NSC 30154;NSC-30154;Pyridine, 2-((2-(dimethylamino)ethyl)amino)-;1,2-Ethanediamine, N,N-dimethyl-N'-2-pyridinyl-;BRN 0132314;2-(2-(Dimethylamino)ethylamino)pyridine;N1,N1-dimethyl-N2-(pyridin-2-yl)ethane-1,2-diamine;N-[2-(dimethylamino)ethyl]pyridin-2-amine;024Q9A52OA;2-(2-(Dimethylamino)ethylamino)-pyridine;Pyridine, 2-[[2-(dimethylamino)ethyl]amino]-;4-22-00-03923 (Beilstein Handbook Reference);NCIStruc1_000247;NCIStruc2_000209;UNII-024Q9A52OA;SCHEMBL4440939;CHEMBL1489836;DTXSID20178533;NCI30154;1, N,N-dimethyl-N'-2-pyridinyl-;CCG-37616;NCGC00013368;AKOS008923119;NCGC00013368-02;NCGC00096484-01;NCI60_002532;N,N-dimethyl-N'-2-pyridyl ethylenediamine;LS-131436;N-[2-(Dimethylamino)ethyl]-2-pyridinamine;CS-0253087;EN300-624216;F76048;PYR_166.1340_2.9;Pyridine, 2-[[(2-(dimethylamino)ethyl]amino]-;N1,N1-dimethyl-N2-(2-pyridinyl)-1,2-ethanediamine;Q63398551;1,2-ETHANEDIAMINE, N1,N1-DIMETHYL-N2-2-PYRIDINYL-;N,N-DIMETHYL-N'-(PYRIDIN-2-YL)ETHANE-1,2-DIAMINE;N1,N1-DIMETHYL-N2-2-PYRIDINYL-1,2-ETHANEDIAMINE

Chemical Property of 2-(2-Pyridylamino)ethyldimethylamine

Chemical Property:

• Vapor Pressure: 0.00396mmHg at 25°C
• Boiling Point: 279.7°Cat760mmHg
• PKA: 9.03±0.28(Predicted)
• Flash Point: 122.9°C
• PSA: 28.16000
• Density: 1.039g/cm³
• LogP: 1.12810
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 165.126597491
• Heavy Atom Count: 12
• Complexity: 114

Purity/Quality:

99% ^*data from raw suppliers

2-(2-(DIMETHYLAMINO)ETHYLAMINO)PYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCNC1=CC=CC=N1

Technology Process of 2-(2-Pyridylamino)ethyldimethylamine

There total 12 articles about 2-(2-Pyridylamino)ethyldimethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

pyridine (110-86-1) + N,N-dimethylethylenediamine (108-00-9) → N,N-dimethyl-N'-(pyridine-2-yl)ethane-1,2-diamine (23826-72-4)

Guidance literature:

With sodium hydride; lithium iodide; In tetrahydrofuran; at 85 ℃; Temperature; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.15227/ORGSYN.098.0363

Reference yield: 75.0%

2-chloropyridine (109-09-1) + N,N-dimethylethylenediamine (108-00-9) → N,N-dimethyl-N'-(pyridine-2-yl)ethane-1,2-diamine (23826-72-4)

Guidance literature:

at 175 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.apcata.2014.04.009

Reference yield: 70.0%

2-aminopyridine (504-29-0) + 2-(N,N-dimethylamino)ethanol (108-01-0) → N,N-dimethyl-N'-(pyridine-2-yl)ethane-1,2-diamine (23826-72-4)

Guidance literature:

With 1,10-Phenanthroline; potassium tert-butylate; nickel dibromide; In toluene; at 130 ℃; for 48h; chemoselective reaction;

DOI:10.1021/acscatal.7b02817

upstream raw materials:

pyridine

N,N-dimethylethylenediamine

2-aminopyridine

2-bromo-pyridine

Downstream raw materials:

Methaferylene

methapyrilene

N,N-dimethyl-N'-[2]pyridyl-N'-[3]thienylmethyl-ethylenediamine

Chlorothen

Refernces

• 1、 -. "Mesoionic insecticide". Paragraph 0161; 0165-0166; 0171. . Retrieved 2020/09/16.
• 2、 Vellakkaran, Mari,Singh, Khushboo,Banerjee, Debasis. "An Efficient and Selective Nickel-Catalyzed Direct N-Alkylation of Anilines with Alcohols". . p. 8152 - 8158. Retrieved 2017/12/08.