3-((tert-butyldimethylsilyl)oxy)-N-(3,5-diiodo-4-methoxyphenyl)-4-methoxybenzamide

Base Information

Chemical Name:3-((tert-butyldimethylsilyl)oxy)-N-(3,5-diiodo-4-methoxyphenyl)-4-methoxybenzamide
CAS No.:1355597-74-8
Molecular Formula:C₂₁H₂₇I₂NO₄Si
Molecular Weight:639.344
Hs Code.:

Synonyms:3-((tert-butyldimethylsilyl)oxy)-N-(3,5-diiodo-4-methoxyphenyl)-4-methoxybenzamide

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Chemical Property of 3-((tert-butyldimethylsilyl)oxy)-N-(3,5-diiodo-4-methoxyphenyl)-4-methoxybenzamide

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Technology Process of 3-((tert-butyldimethylsilyl)oxy)-N-(3,5-diiodo-4-methoxyphenyl)-4-methoxybenzamide

There total 9 articles about 3-((tert-butyldimethylsilyl)oxy)-N-(3,5-diiodo-4-methoxyphenyl)-4-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1355597-64-6
3-((tert-butyldimethylsilyl)oxy)-4-methoxybenzoic (ethyl carbonic) anhydride

: 496801-28-6
3,5-diiodo-4-methoxyaniline

: 1355597-74-8
3-((tert-butyldimethylsilyl)oxy)-N-(3,5-diiodo-4-methoxyphenyl)-4-methoxybenzamide

Guidance literature:: 3,5-diiodo-4-methoxyaniline; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.666667h; Inert atmosphere;

3-((tert-butyldimethylsilyl)oxy)-4-methoxybenzoic (ethyl carbonic) anhydride; In tetrahydrofuran; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/ml200149g

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1355597-74-8
3-((tert-butyldimethylsilyl)oxy)-N-(3,5-diiodo-4-methoxyphenyl)-4-methoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere

1.2: 4 h / 80 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 0.67 h / 0 - 20 °C / Inert atmosphere

3.2: 18 h / 20 °C / Inert atmosphere

With sodium hydride; triethylamine; In tetrahydrofuran; mineral oil;
DOI:10.1021/ml200149g

Reference yield:

: 621-59-0
isovanillin

: 1355597-74-8
3-((tert-butyldimethylsilyl)oxy)-N-(3,5-diiodo-4-methoxyphenyl)-4-methoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: tert.-butylhydroperoxide; copper(l) chloride / acetonitrile / 24 h / 20 °C

3.1: triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 0.67 h / 0 - 20 °C / Inert atmosphere

4.2: 18 h / 20 °C / Inert atmosphere

With tert.-butylhydroperoxide; sodium hydride; triethylamine; copper(l) chloride; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ml200149g