3-((tert-butyldimethylsilyl)oxy)-N-(3,5-diiodo-4-methoxyphenyl)-4-methoxybenzothioamide

Base Information

Chemical Name:3-((tert-butyldimethylsilyl)oxy)-N-(3,5-diiodo-4-methoxyphenyl)-4-methoxybenzothioamide
CAS No.:1355597-80-6
Molecular Formula:C₂₁H₂₇I₂NO₃SSi
Molecular Weight:655.411
Hs Code.:

Synonyms:3-((tert-butyldimethylsilyl)oxy)-N-(3,5-diiodo-4-methoxyphenyl)-4-methoxybenzothioamide

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Chemical Property of 3-((tert-butyldimethylsilyl)oxy)-N-(3,5-diiodo-4-methoxyphenyl)-4-methoxybenzothioamide

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Technology Process of 3-((tert-butyldimethylsilyl)oxy)-N-(3,5-diiodo-4-methoxyphenyl)-4-methoxybenzothioamide

There total 11 articles about 3-((tert-butyldimethylsilyl)oxy)-N-(3,5-diiodo-4-methoxyphenyl)-4-methoxybenzothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1355597-74-8
3-((tert-butyldimethylsilyl)oxy)-N-(3,5-diiodo-4-methoxyphenyl)-4-methoxybenzamide

: 1355597-80-6
3-((tert-butyldimethylsilyl)oxy)-N-(3,5-diiodo-4-methoxyphenyl)-4-methoxybenzothioamide

Guidance literature:: With Lawessons reagent; In tetrahydrofuran; at 70 ℃; for 4h; Inert atmosphere;
DOI:10.1021/ml200149g

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1355597-80-6
3-((tert-butyldimethylsilyl)oxy)-N-(3,5-diiodo-4-methoxyphenyl)-4-methoxybenzothioamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere

1.2: 4 h / 80 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 0.67 h / 0 - 20 °C / Inert atmosphere

3.2: 18 h / 20 °C / Inert atmosphere

4.1: Lawessons reagent / tetrahydrofuran / 4 h / 70 °C / Inert atmosphere

With Lawessons reagent; sodium hydride; triethylamine; In tetrahydrofuran; mineral oil;
DOI:10.1021/ml200149g

Reference yield:

: 621-59-0
isovanillin

: 1355597-80-6
3-((tert-butyldimethylsilyl)oxy)-N-(3,5-diiodo-4-methoxyphenyl)-4-methoxybenzothioamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: tert.-butylhydroperoxide; copper(l) chloride / acetonitrile / 24 h / 20 °C

3.1: triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 0.67 h / 0 - 20 °C / Inert atmosphere

4.2: 18 h / 20 °C / Inert atmosphere

5.1: Lawessons reagent / tetrahydrofuran / 4 h / 70 °C / Inert atmosphere

With Lawessons reagent; tert.-butylhydroperoxide; sodium hydride; triethylamine; copper(l) chloride; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ml200149g