5-(3-((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-1-(3,5-diiodo-4-methoxyphenyl)-1H-tetrazole

Base Information

Chemical Name:5-(3-((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-1-(3,5-diiodo-4-methoxyphenyl)-1H-tetrazole
CAS No.:1355597-86-2
Molecular Formula:C₂₁H₂₆I₂N₄O₃Si
Molecular Weight:664.357
Hs Code.:

Synonyms:5-(3-((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-1-(3,5-diiodo-4-methoxyphenyl)-1H-tetrazole

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Chemical Property of 5-(3-((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-1-(3,5-diiodo-4-methoxyphenyl)-1H-tetrazole

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Technology Process of 5-(3-((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-1-(3,5-diiodo-4-methoxyphenyl)-1H-tetrazole

There total 12 articles about 5-(3-((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-1-(3,5-diiodo-4-methoxyphenyl)-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1355597-80-6
3-((tert-butyldimethylsilyl)oxy)-N-(3,5-diiodo-4-methoxyphenyl)-4-methoxybenzothioamide

: 1355597-86-2
5-(3-((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-1-(3,5-diiodo-4-methoxyphenyl)-1H-tetrazole

Guidance literature:: With trimethylsilylazide; mercury(II) diacetate; In tetrahydrofuran; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ml200149g

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1355597-86-2
5-(3-((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-1-(3,5-diiodo-4-methoxyphenyl)-1H-tetrazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere

1.2: 4 h / 80 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 0.67 h / 0 - 20 °C / Inert atmosphere

3.2: 18 h / 20 °C / Inert atmosphere

4.1: Lawessons reagent / tetrahydrofuran / 4 h / 70 °C / Inert atmosphere

5.1: trimethylsilylazide; mercury(II) diacetate / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

With Lawessons reagent; trimethylsilylazide; mercury(II) diacetate; sodium hydride; triethylamine; In tetrahydrofuran; mineral oil;
DOI:10.1021/ml200149g

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 1355597-86-2
5-(3-((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-1-(3,5-diiodo-4-methoxyphenyl)-1H-tetrazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; sodium chlorite; sodium iodide / methanol; water / 18 h / 0 - 20 °C

2.1: potassium carbonate / acetone / 18 h / 0 - 65 °C / Inert atmosphere

3.1: tin(ll) chloride / ethanol; ethyl acetate / 2 h / 70 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 0.67 h / 0 - 20 °C / Inert atmosphere

4.2: 18 h / 20 °C / Inert atmosphere

5.1: Lawessons reagent / tetrahydrofuran / 4 h / 70 °C / Inert atmosphere

6.1: trimethylsilylazide; mercury(II) diacetate / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

With Lawessons reagent; hydrogenchloride; sodium chlorite; trimethylsilylazide; mercury(II) diacetate; sodium hydride; potassium carbonate; sodium iodide; tin(ll) chloride; In tetrahydrofuran; methanol; ethanol; water; ethyl acetate; acetone;
DOI:10.1021/ml200149g