4-cyclohexyl-benzoic acid ethyl ester

Base Information

• Chemical Name: 4-cyclohexyl-benzoic acid ethyl ester
• CAS No.: 959141-01-6
• Molecular Formula: C₁₅H₂₀O₂
• Molecular Weight: 232.323
• Mol file: 959141-01-6.mol

Synonyms:4-cyclohexyl-benzoic acid ethyl ester

Chemical Property of 4-cyclohexyl-benzoic acid ethyl ester

Chemical Property:

Purity/Quality:

4-Cyclohexylbenzoicacidethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-cyclohexyl-benzoic acid ethyl ester

There total 13 articles about 4-cyclohexyl-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethanol (64-17-5) + 4-cyclohexylbenzoic acid (20029-52-1) → 4-cyclohexyl-benzoic acid ethyl ester (959141-01-6)

Guidance literature:

With sulfuric acid; for 5h; Reflux;

Reference yield: 96.0%

1-bromocyclohexane (108-85-0) + Ethyl 4-bromobenzoate (5798-75-4) → 4-cyclohexyl-benzoic acid ethyl ester (959141-01-6)

Guidance literature:

With pyridine; manganese; diisopropylphenylphosphane; trifluoroacetic acid; cobalt(II) bromide; In N,N-dimethyl-formamide; at 30 ℃; for 15h;

DOI:10.1002/chem.201000178

Reference yield: 95.0%

ethyl 4-(N,N,N-trimethylammonium)-1-benzoate triflate (124915-06-6) + cyclohexylmagnesium bromide (931-50-0) → 4-cyclohexyl-benzoic acid ethyl ester (959141-01-6)

Guidance literature:

With iron(III)-acetylacetonate; copper(II) bis(trifluoromethanesulfonate); In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 25 ℃; for 1h; Reagent/catalyst; Solvent; Catalytic behavior; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tet.2013.09.039

upstream raw materials:

ethanol

4-cyclohexylbenzoic acid

4-iodobenzoic acid ethyl ester

cyclohexylmagnesium bromide

Downstream raw materials:

Hydroxy-bis-(3-cyclohexyl-phenyl)-(4-cyclohexyl-phenyl)-methan

4-cyclohexylbenzyl chloride

4-(4-cyclohexylbenzyloxy)benzaldehyde

5-(4-(4-cyclohexylbenzyloxy)benzylidene)-3-methyl-2-(4-nitrophenyimino)thiazolidin-4-one