Benzyl 4-(biphenyl-3-yl)-6-((tert-butyldimethylsilyloxy)methyl)-3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-5,6-dihydropyridine-1(2H)-carboxylate

Base Information

Chemical Name:Benzyl 4-(biphenyl-3-yl)-6-((tert-butyldimethylsilyloxy)methyl)-3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-5,6-dihydropyridine-1(2H)-carboxylate
CAS No.:1361293-61-9
Molecular Formula:C₄₃H₄₈Cl₂N₂O₄Si
Molecular Weight:755.857
Hs Code.:

Benzyl 4-(biphenyl-3-yl)-6-((tert-butyldimethylsilyloxy)methyl)-3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-5,6-dihydropyridine-1(2H)-carboxylate

Synonyms:Benzyl 4-(biphenyl-3-yl)-6-((tert-butyldimethylsilyloxy)methyl)-3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-5,6-dihydropyridine-1(2H)-carboxylate

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Chemical Property of Benzyl 4-(biphenyl-3-yl)-6-((tert-butyldimethylsilyloxy)methyl)-3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-5,6-dihydropyridine-1(2H)-carboxylate

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Technology Process of Benzyl 4-(biphenyl-3-yl)-6-((tert-butyldimethylsilyloxy)methyl)-3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-5,6-dihydropyridine-1(2H)-carboxylate

There total 5 articles about Benzyl 4-(biphenyl-3-yl)-6-((tert-butyldimethylsilyloxy)methyl)-3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-5,6-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 625437-42-5
cyclopropyl-(2,3-dichlorobenzyl)amine

: 1361293-43-7
Ethyl 3-((benzyloxycarbonyl)(3-ethoxy-3-oxopropyl)amino)-4-(tert-butyldimethylsilyloxy)butanoate

: 5122-95-2
3-Biphenylboronic acid

: 1361293-61-9
Benzyl 4-(biphenyl-3-yl)-6-((tert-butyldimethylsilyloxy)methyl)-3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-5,6-dihydropyridine-1(2H)-carboxylate

: 1361293-62-0
benzyl 4-(biphenyl-3-yl)-2-((tert-butyldimethylsilyloxy)methyl)-3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Ethyl 3-((benzyloxycarbonyl)(3-ethoxy-3-oxopropyl)amino)-4-(tert-butyldimethylsilyloxy)butanoate; With sodium; In ethanol; toluene; at 20 ℃; for 48h; Inert atmosphere;

With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

N,N-phenylbistrifluoromethane-sulfonimide; cyclopropyl-(2,3-dichlorobenzyl)amine; 3-Biphenylboronic acid;

Reference yield:

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 1361293-61-9
Benzyl 4-(biphenyl-3-yl)-6-((tert-butyldimethylsilyloxy)methyl)-3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-5,6-dihydropyridine-1(2H)-carboxylate

: 1361293-62-0
benzyl 4-(biphenyl-3-yl)-2-((tert-butyldimethylsilyloxy)methyl)-3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 4.33 h / 0 °C / Inert atmosphere

1.2: 0.5 h

2.1: sodium / toluene; ethanol / 48 h / 20 °C / Inert atmosphere

2.2: 0.5 h / 0 °C / Inert atmosphere

With sodium; sodium tris(acetoxy)borohydride; acetic acid; In ethanol; dichloromethane; toluene;

Reference yield:

: 102191-92-4
tert-butyldimethylsiloxyacetaldehyde

: 1361293-61-9
Benzyl 4-(biphenyl-3-yl)-6-((tert-butyldimethylsilyloxy)methyl)-3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-5,6-dihydropyridine-1(2H)-carboxylate

: 1361293-62-0
benzyl 4-(biphenyl-3-yl)-2-((tert-butyldimethylsilyloxy)methyl)-3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 5 h / 20 - 50 °C / Inert atmosphere

2.1: ethanol / 20 °C / Inert atmosphere; Reflux

3.1: sodium hydrogencarbonate / 1,4-dioxane / 0 - 20 °C / Inert atmosphere

4.1: sodium / toluene; ethanol / 48 h / 20 °C / Inert atmosphere

4.2: 0.5 h / 0 °C / Inert atmosphere

With sodium; sodium hydrogencarbonate; In 1,4-dioxane; ethanol; toluene;