(R)-1-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)ethanone

Base Information

• Chemical Name: (R)-1-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)ethanone
• CAS No.: 1421253-52-2
• Molecular Formula: C₄₀H₄₆N₆O₃S
• Molecular Weight: 690.91
• Mol file: 1421253-52-2.mol

Synonyms:(R)-1-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)ethanone

Chemical Property of (R)-1-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)ethanone

There total 15 articles about (R)-1-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1-tosyl-1H-indol-4-yl)-4-(2-methylpiperazin-1-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine trifluoroacetate + acetic anhydride (108-24-7) → (R)-1-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)ethanone (1421253-52-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.75h;

Reference yield:

5-isopropyl-2-methylphenyl trifluoromethanesulfonate (63028-16-0) → (R)-1-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)ethanone (1421253-52-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: XPhos; caesium carbonate; palladium diacetate / tetrahydrofuran / 1.5 h / 120 °C / Microwave irradiation; Inert atmosphere; Sealed tube

2.1: hydrogenchloride / water; ethanol / 15 h / 68 °C

2.2: 0.42 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 15 h / 125 °C

4.1: dichloromethane / 0.5 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h / 20 °C

With hydrogenchloride; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; XPhos; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water;

Reference yield:

carvacrol (499-75-2) → (R)-1-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)ethanone (1421253-52-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2.1: XPhos; caesium carbonate; palladium diacetate / tetrahydrofuran / 1.5 h / 120 °C / Microwave irradiation; Inert atmosphere; Sealed tube

3.1: hydrogenchloride / water; ethanol / 15 h / 68 °C

3.2: 0.42 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 15 h / 125 °C

5.1: dichloromethane / 0.5 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h / 20 °C

With pyridine; hydrogenchloride; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; XPhos; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water;

upstream raw materials:

5-isopropyl-2-methylphenyl trifluoromethanesulfonate

carvacrol

6-benzyl-2-chloro-4-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

6-benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidine

Downstream raw materials:

(R)-1-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)ethanone