(R)-1-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)ethanone

Base Information

Chemical Name:(R)-1-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)ethanone
CAS No.:1421250-74-9
Molecular Formula:C₃₃H₄₀N₆O
Molecular Weight:536.72
Hs Code.:

Synonyms:(R)-1-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)ethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)ethanone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-1-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)ethanone

There total 16 articles about (R)-1-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421253-52-2
(R)-1-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)ethanone

: 1421250-74-9
(R)-1-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)ethanone

Guidance literature:: With ammonium hydroxide; potassium hydroxide; In ethanol; at 100 ℃; for 1h; Microwave irradiation;

Reference yield:

: 63028-16-0
5-isopropyl-2-methylphenyl trifluoromethanesulfonate

: 1421250-74-9
(R)-1-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: XPhos; caesium carbonate; palladium diacetate / tetrahydrofuran / 1.5 h / 120 °C / Microwave irradiation; Inert atmosphere; Sealed tube

2.1: hydrogenchloride / water; ethanol / 15 h / 68 °C

2.2: 0.42 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 15 h / 125 °C

4.1: dichloromethane / 0.5 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h / 20 °C

6.1: ammonium hydroxide; potassium hydroxide / ethanol / 1 h / 100 °C / Microwave irradiation

With hydrogenchloride; ammonium hydroxide; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; XPhos; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water;

Reference yield:

: 499-75-2
carvacrol

: 1421250-74-9
(R)-1-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2.1: XPhos; caesium carbonate; palladium diacetate / tetrahydrofuran / 1.5 h / 120 °C / Microwave irradiation; Inert atmosphere; Sealed tube

3.1: hydrogenchloride / water; ethanol / 15 h / 68 °C

3.2: 0.42 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 15 h / 125 °C

5.1: dichloromethane / 0.5 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h / 20 °C

7.1: ammonium hydroxide; potassium hydroxide / ethanol / 1 h / 100 °C / Microwave irradiation

With pyridine; hydrogenchloride; ammonium hydroxide; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; XPhos; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water;