ethyl 3,4,7-tri-O-benzyl-5-O-((2-naphthyl)methyl)-1-deoxy-1-ethoxysulfonyl-2-thio-α-D-gluco-hept-2-ulopyranoside

Base Information

Chemical Name:ethyl 3,4,7-tri-O-benzyl-5-O-((2-naphthyl)methyl)-1-deoxy-1-ethoxysulfonyl-2-thio-α-D-gluco-hept-2-ulopyranoside
CAS No.:1381871-18-6
Molecular Formula:C₄₃H₄₈O₈S₂
Molecular Weight:756.981
Hs Code.:

Synonyms:ethyl 3,4,7-tri-O-benzyl-5-O-((2-naphthyl)methyl)-1-deoxy-1-ethoxysulfonyl-2-thio-α-D-gluco-hept-2-ulopyranoside

Suppliers and Price of ethyl 3,4,7-tri-O-benzyl-5-O-((2-naphthyl)methyl)-1-deoxy-1-ethoxysulfonyl-2-thio-α-D-gluco-hept-2-ulopyranoside

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 3,4,7-tri-O-benzyl-5-O-((2-naphthyl)methyl)-1-deoxy-1-ethoxysulfonyl-2-thio-α-D-gluco-hept-2-ulopyranoside

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 3,4,7-tri-O-benzyl-5-O-((2-naphthyl)methyl)-1-deoxy-1-ethoxysulfonyl-2-thio-α-D-gluco-hept-2-ulopyranoside

There total 2 articles about ethyl 3,4,7-tri-O-benzyl-5-O-((2-naphthyl)methyl)-1-deoxy-1-ethoxysulfonyl-2-thio-α-D-gluco-hept-2-ulopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1381871-16-4
3,4,7-tri-O-benzyl-5-O-((2-naphthyl)methyl)-1-deoxy-1-ethoxysulfonyl-α-D-gluco-hept-2-ulopyranose

: 75-08-1
ethanethiol

: 1381871-18-6
ethyl 3,4,7-tri-O-benzyl-5-O-((2-naphthyl)methyl)-1-deoxy-1-ethoxysulfonyl-2-thio-α-D-gluco-hept-2-ulopyranoside

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2012.04.067

Reference yield:

: 2,3,6-tri-O-benzyl-4-O-((2-naphthyl)methyl)-α,β-D-glucopyranose

: 1381871-18-6
ethyl 3,4,7-tri-O-benzyl-5-O-((2-naphthyl)methyl)-1-deoxy-1-ethoxysulfonyl-2-thio-α-D-gluco-hept-2-ulopyranoside

Guidance literature:: Multi-step reaction with 3 steps

1.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.25 h / -60 °C / Inert atmosphere

2.2: 3 h / -78 - -60 °C / Inert atmosphere

2.3: Inert atmosphere

3.1: boron trifluoride diethyl etherate / dichloromethane / 0 °C / Inert atmosphere

With n-butyllithium; boron trifluoride diethyl etherate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 1.1: Dess-Martin oxidation;
DOI:10.1016/j.tet.2012.04.067

Reference yield: 76.0%

: 67-56-1
methanol

: 1381871-18-6
ethyl 3,4,7-tri-O-benzyl-5-O-((2-naphthyl)methyl)-1-deoxy-1-ethoxysulfonyl-2-thio-α-D-gluco-hept-2-ulopyranoside

: 1381871-26-6
methyl 3,4,7-tri-O-benzyl-5-O-((2-naphthyl)methyl)-1-deoxy-1-ethoxysulfonyl-α-D-gluco-hept-2-ulopyranoside

: 1381871-27-7
methyl 3,4,7-tri-O-benzyl-5-O-((2-naphthyl)methyl)-1-deoxy-1-ethoxysulfonyl-β-D-gluco-hept-2-ulopyranoside

Guidance literature:: With N-iodo-succinimide; trifluorormethanesulfonic acid; In tetrahydrofuran; dichloromethane; at -20 ℃; for 0.333333h; optical yield given as %de; Inert atmosphere; Molecular sieve;
DOI:10.1016/j.tet.2012.04.067