methyl 2-(2'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-3-hydroxy-3-(2''-O-methoxymethyl-4''-methoxyphenyl)propanoate

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Chemical Name:methyl 2-(2'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-3-hydroxy-3-(2''-O-methoxymethyl-4''-methoxyphenyl)propanoate
CAS No.:209404-22-8
Molecular Formula:C₂₆H₃₈O₈Si
Molecular Weight:506.668
Hs Code.:

Synonyms:methyl 2-(2'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-3-hydroxy-3-(2''-O-methoxymethyl-4''-methoxyphenyl)propanoate

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Chemical Property of methyl 2-(2'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-3-hydroxy-3-(2''-O-methoxymethyl-4''-methoxyphenyl)propanoate

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Technology Process of methyl 2-(2'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-3-hydroxy-3-(2''-O-methoxymethyl-4''-methoxyphenyl)propanoate

There total 3 articles about methyl 2-(2'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-3-hydroxy-3-(2''-O-methoxymethyl-4''-methoxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 124555-63-1
4-methoxy-2-methoxymethoxy benzaldehyde

: 209404-18-2
methyl 2-tert-butyldimethylsilyloxy-4-methoxyphenylacetate

: 209404-22-8
methyl 2-(2'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-3-hydroxy-3-(2''-O-methoxymethyl-4''-methoxyphenyl)propanoate

Guidance literature:: methyl 2-tert-butyldimethylsilyloxy-4-methoxyphenylacetate; With lithium diisopropyl amide; In diethyl ether; at -78 ℃; for 0.5h;

4-methoxy-2-methoxymethoxy benzaldehyde; In diethyl ether; at -78 - 0 ℃;
DOI:10.1016/S0040-4020(01)00679-2

Reference yield:

: 209404-16-0
methyl (2-benzyloxy-4-methoxyphenyl)acetate

: 209404-22-8
methyl 2-(2'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-3-hydroxy-3-(2''-O-methoxymethyl-4''-methoxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 83 percent / H₂ / Pd/C / acetone / 5 h

2.1: 90 percent / imidazole / dimethylformamide / 16 h / 25 °C

3.1: LDA / diethyl ether / 0.5 h / -78 °C

3.2: 69 percent / diethyl ether / -78 - 0 °C

With 1H-imidazole; hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In diethyl ether; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4020(01)00679-2

Reference yield:

: 212688-07-8
methyl (2-hydroxy-4-methoxyphenyl)acetate

: 209404-22-8
methyl 2-(2'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-3-hydroxy-3-(2''-O-methoxymethyl-4''-methoxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / imidazole / dimethylformamide / 16 h / 25 °C

2.1: LDA / diethyl ether / 0.5 h / -78 °C

2.2: 69 percent / diethyl ether / -78 - 0 °C

With 1H-imidazole; lithium diisopropyl amide; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)00679-2