2-cyclohexyl-2,2-diphenylacetaldehyde

Base Information

• Chemical Name: 2-cyclohexyl-2,2-diphenylacetaldehyde
• CAS No.: 871878-35-2
• Molecular Formula: C₂₀H₂₂O
• Molecular Weight: 278.394
• Mol file: 871878-35-2.mol

Synonyms:2-cyclohexyl-2,2-diphenylacetaldehyde

Chemical Property of 2-cyclohexyl-2,2-diphenylacetaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-cyclohexyl-2,2-diphenylacetaldehyde

There total 7 articles about 2-cyclohexyl-2,2-diphenylacetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-cyclohexyl-2,2-diphenylacetonitrile (94684-49-8) → 2-cyclohexyl-2,2-diphenylacetaldehyde (871878-35-2)

Guidance literature:

With diisobutylaluminium hydride; In cyclohexylamine; toluene; at -78 - 20 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1002/adsc.201400969

Reference yield:

cyclohexylmagnesium bromide (931-50-0) → 2-cyclohexyl-2,2-diphenylacetaldehyde (871878-35-2)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: sulfuric acid

With diethyl ether; sulfuric acid;

Reference yield:

Cyclohexyl iodide (626-62-0) → 2-cyclohexyl-2,2-diphenylacetaldehyde (871878-35-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C

1.2: 12 h

2.1: diisobutylaluminium hydride / toluene; cyclohexylamine / 12 h / -78 - 20 °C / Schlenk technique; Inert atmosphere

With sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; cyclohexylamine; toluene; mineral oil;

DOI:10.1002/adsc.201400969

upstream raw materials:

sulfuric acid

1-cyclohexyl-1,2-diphenylethane-1,2-diol

oxalic acid

2-hydroxy-2-phenylacetophenone

Downstream raw materials:

formic acid

(cyclohexylmethylene)dibenzene

1-cyclohexyl-2,2-diphenyl-ethanone