3-bromo-N-(4-chloro-2-((2-(dimethylamino)ethyl)carbamoyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

Base Information

• Chemical Name: 3-bromo-N-(4-chloro-2-((2-(dimethylamino)ethyl)carbamoyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide
• CAS No.: 1079956-75-4
• Molecular Formula: C₂₁H₂₁BrCl₂N₆O₂
• Molecular Weight: 540.247
• Mol file: 1079956-75-4.mol

Synonyms:3-bromo-N-(4-chloro-2-((2-(dimethylamino)ethyl)carbamoyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

Chemical Property of 3-bromo-N-(4-chloro-2-((2-(dimethylamino)ethyl)carbamoyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-bromo-N-(4-chloro-2-((2-(dimethylamino)ethyl)carbamoyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

There total 7 articles about 3-bromo-N-(4-chloro-2-((2-(dimethylamino)ethyl)carbamoyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

6-chloro-2-(3-bromo-1-(3-chloropyridin-2-yl)-1Hpyrazol-5-yl)-8-methyl-4H-benzo[d][1,3]oxazin-4-one (500011-87-0) + N,N-dimethylethylenediamine (108-00-9) → 3-bromo-N-(4-chloro-2-((2-(dimethylamino)ethyl)carbamoyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide (1079956-75-4)

Guidance literature:

In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2014.02.053

Reference yield:

(3-chloro-2-pyridyl)hydrazine (22841-92-5) → 3-bromo-N-(4-chloro-2-((2-(dimethylamino)ethyl)carbamoyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide (1079956-75-4)

Guidance literature:

Multi-step reaction with 6 steps

1: Reflux

2: phosphorus(V) oxybromide / acetonitrile

3: sulfuric acid; dipotassium peroxodisulfate

4: sodium hydroxide / methanol

5: methanesulfonyl chloride; triethylamine

6: dichloromethane / 0 - 20 °C

With dipotassium peroxodisulfate; sulfuric acid; methanesulfonyl chloride; triethylamine; sodium hydroxide; phosphorus(V) oxybromide; In methanol; dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2014.02.053

Reference yield:

ethyl 1-(3-chloropyridin-2-yl)-3-hydroxy-4,5-dihydro-1H-pyrazole-5-carboxylate (500011-88-1) → 3-bromo-N-(4-chloro-2-((2-(dimethylamino)ethyl)carbamoyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide (1079956-75-4)

Guidance literature:

Multi-step reaction with 5 steps

1: phosphorus(V) oxybromide / acetonitrile

2: sulfuric acid; dipotassium peroxodisulfate

3: sodium hydroxide / methanol

4: methanesulfonyl chloride; triethylamine

5: dichloromethane / 0 - 20 °C

With dipotassium peroxodisulfate; sulfuric acid; methanesulfonyl chloride; triethylamine; sodium hydroxide; phosphorus(V) oxybromide; In methanol; dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2014.02.053

upstream raw materials:

6-chloro-2-(3-bromo-1-(3-chloropyridin-2-yl)-1Hpyrazol-5-yl)-8-methyl-4H-benzo[d][1,3]oxazin-4-one

N,N-dimethylethylenediamine

(3-chloro-2-pyridyl)hydrazine

ethyl 1-(3-chloropyridin-2-yl)-3-hydroxy-4,5-dihydro-1H-pyrazole-5-carboxylate