4-chloro-5-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

Base Information

Chemical Name:4-chloro-5-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine
CAS No.:1032815-08-9
Molecular Formula:C₁₆H₁₃ClN₂O₄S
Molecular Weight:364.809
Hs Code.:

Synonyms:4-chloro-5-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-chloro-5-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 4-chloro-5-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

There total 6 articles about 4-chloro-5-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1032815-07-8
4-chloro-1-(phenylsulfonyl)-1H-pyrrolo [2,3-b]pyridine-5-carbaldehyde

: 107-21-1
ethylene glycol

: 1032815-08-9
4-chloro-5-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With p-toluenesulfonic acid monohydrate; In toluene; at 20 ℃; for 9h; Reflux; Large scale;

Reference yield:

: 55052-28-3
4-chloro-7-azaindole

: 1032815-08-9
4-chloro-5-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 20 h / 25 °C

2.1: sec.-butyllithium / cyclohexane; tetrahydrofuran / 8 h / -75 - -60 °C / Inert atmosphere; Large scale

2.2: 2 h / -75 - -65 °C / Large scale

3.1: caesium carbonate / N,N-dimethyl-formamide / 0.33 h / 0 - 5 °C / Large scale

3.2: 1 h / 10 °C / Large scale

4.1: p-toluenesulfonic acid monohydrate / toluene / 9 h / 20 °C / Reflux; Large scale

With p-toluenesulfonic acid monohydrate; sec.-butyllithium; sodium hydride; caesium carbonate; In tetrahydrofuran; cyclohexane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 271-63-6
7-Azaindole

: 1032815-08-9
4-chloro-5-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 8 h / 0 - 10 °C / Large scale

2.1: methanesulfonyl chloride / N,N-dimethyl-formamide / 2 h / 50 - 90 °C / Large scale

3.1: sodium hydride / mineral oil; tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3.2: 20 h / 25 °C

4.1: sec.-butyllithium / cyclohexane; tetrahydrofuran / 8 h / -75 - -60 °C / Inert atmosphere; Large scale

4.2: 2 h / -75 - -65 °C / Large scale

5.1: caesium carbonate / N,N-dimethyl-formamide / 0.33 h / 0 - 5 °C / Large scale

5.2: 1 h / 10 °C / Large scale

6.1: p-toluenesulfonic acid monohydrate / toluene / 9 h / 20 °C / Reflux; Large scale

With p-toluenesulfonic acid monohydrate; sec.-butyllithium; sodium hydride; caesium carbonate; methanesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; cyclohexane; N,N-dimethyl-formamide; toluene; mineral oil;